All Phenotypes Gt(ROSA)26Sor<tm2(SS18)Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^tm2(SS18)Mrc
targeted mutation 2, Mario R Capecchi
MGI:3710095

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Myf6^tm1(cre)Mrc/Myf6^tm1(cre)Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3710996
cn2	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Pax7^tm1(cre)Mrc/Pax7^tm1(cre)Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3710998
cn3	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Pax3^tm1(cre)Joe/Pax3^tm1(cre)Joe	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3711001
cn4	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Hprt1^{tm1(CAG-cre)Mnn}/Hprt1^{tm1(CAG-cre)Mnn}	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3711003
cn5	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Myf5^tm1(cre)Mrc/Myf5^tm1(cre)Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3711005

Allelic Composition	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Myf6^tm1(cre)Mrc/Myf6^tm1(cre)Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm2(SS18)Mrc mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Myf6^tm1(cre)Mrc mutation (0 available); any Myf6 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:120967 )

• mice die by 6 months of age

neoplasm

neoplasm ( J:120967 )

N	• unlike in other Gt(ROSA)26Sor^tm2(SS18)Mrc homozygously activated mice, no tumors form

muscle

abnormal skeletal muscle morphology ( J:120967 )

• intrafiber vacuolation is present in some muscle fibers

• apoptosis of differentiated skeletal muscle fibers is increased

centrally nucleated skeletal muscle fibers ( J:120967 )

• central nuclei are present in some muscle fibers

myopathy ( J:120967 )

• myopathy is characterized by abnormal wavy fiber and limited rhabdomyolysis

Allelic Composition	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Pax7^tm1(cre)Mrc/Pax7^tm1(cre)Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm2(SS18)Mrc mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Pax7^tm1(cre)Mrc mutation (3 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:120967 )

• no live embryos are recovered

Allelic Composition	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Pax3^tm1(cre)Joe/Pax3^tm1(cre)Joe
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm2(SS18)Mrc mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Pax3^tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:120967 )

• no embryos are recovered at E13.5 but are present at E10.5

Allelic Composition	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Hprt1^{tm1(CAG-cre)Mnn}/Hprt1^{tm1(CAG-cre)Mnn}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm2(SS18)Mrc mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Hprt1^{tm1(CAG-cre)Mnn} mutation (1 available); any Hprt1 mutation (1274 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:120967 )

• no pups were recovered

Allelic Composition	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Myf5^tm1(cre)Mrc/Myf5^tm1(cre)Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm2(SS18)Mrc mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Myf5^tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:120967 )

• about 8% of mice die by 2 months of age

neoplasm

increased tumor incidence ( J:120967 )

• at 3 to 5 months, 18 of 18 surviving mice developed multiple tumors (3 to 5 per mouse) compared to over 100 control mice who did not develop tumors at more than 1 year of age

• however, mice that died prior to 2 months of age did not have tumors and did not die from tumor-related causes

• most tumors are located within the skeletal muscle in the limbs and intercostals regions with some non-skeletal muscle tissues (such as the cerebellum) harboring tumors

• tumors are vascularized, hemorrhagic and cystic spaces are detected in large tumors

increased sarcoma incidence ( J:120967 )

• synovial sarcomas are detected with monophasic (13) outnumbering biphasic (3)

• myxoid and fibrous changes are observed

growth/size/body

decreased body size ( J:120967 )

• about 8% of mice are born small

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
synovial sarcoma		DOID:5485	OMIM:300813	J:120967

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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