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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cxcr6tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3710094
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cxcr6tm1Lex/Cxcr6tm1Lex involves: 129S/SvEvBrd * C57BL/6J MGI:3711064
ht2
 		Cxcr6tm1Lex/Cxcr6+ involves: 129S/SvEvBrd * C57BL/6J MGI:3711065


Genotype
MGI:3711064
hm1
Allelic
Composition		 Cxcr6tm1Lex/Cxcr6tm1Lex
Genetic
Background		 involves: 129S/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr6tm1Lex mutation (1 available); any Cxcr6 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:120952 )
N
• mice are fertile

nervous system
increased medulloblastoma incidence ( J:120952 )
• after 12 months of age, a small number of mice (2.9%) develop medulloblastomas in the cerebellum that are glial fibrillary acidic protein and synaptophysin positive

neoplasm
increased medulloblastoma incidence ( J:120952 )
• after 12 months of age, a small number of mice (2.9%) develop medulloblastomas in the cerebellum that are glial fibrillary acidic protein and synaptophysin positive




Genotype
MGI:3711065
ht2
Allelic
Composition		 Cxcr6tm1Lex/Cxcr6+
Genetic
Background		 involves: 129S/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr6tm1Lex mutation (1 available); any Cxcr6 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased medulloblastoma incidence ( J:120952 )
• after 12 months of age, a small number of mice (4.2%) develop medulloblastomas in the cerebellum that are glial fibrillary acidic protein and synaptophysin positive

nervous system
increased medulloblastoma incidence ( J:120952 )
• after 12 months of age, a small number of mice (4.2%) develop medulloblastomas in the cerebellum that are glial fibrillary acidic protein and synaptophysin positive




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory