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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir208atm1.1Eno
targeted mutation 1.1, Eric N Olson
MGI:3709980
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mir208atm1.1Eno/Mir208atm1.1Eno involves: C57BL/6 MGI:3711774
cx2
 		Mir208atm1.1Eno/Mir208atm1.1Eno
Tg(Myh6-Ppp3ca)37Eno/0 		involves: C57BL/6 * FVB MGI:3711839


Genotype
MGI:3711774
hm1
Allelic
Composition		 Mir208atm1.1Eno/Mir208atm1.1Eno
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir208atm1.1Eno mutation (0 available); any Mir208a mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal myocardium layer morphology ( J:120908 )
• in response to thoracic aortic banding (TAB), mutant animals show almost no cardiomyocyte hypertrophy or fibrosis
abnormal heart left ventricle morphology ( J:120908 )
• left ventricular diameter increases during systole
abnormal cardiovascular system physiology ( J:120908 )
• in mice >6 months of age, cardiac function declines
• in response to TAB, null animals display a blunted hypertrophic response
decreased cardiac muscle contractility ( J:120908 )
• slight reduction in contractility compared to wild-type at 2 months of age
• in response to thoracic aortic banding (TAB), contractility is reduced

muscle
abnormal myocardium layer morphology ( J:120908 )
• in response to thoracic aortic banding (TAB), mutant animals show almost no cardiomyocyte hypertrophy or fibrosis
decreased cardiac muscle contractility ( J:120908 )
• slight reduction in contractility compared to wild-type at 2 months of age
• in response to thoracic aortic banding (TAB), contractility is reduced
abnormal sarcomere morphology ( J:120908 )
• in mice >6 months of age, abnormalities in sarcomere structure are observed




Genotype
MGI:3711839
cx2
Allelic
Composition		 Mir208atm1.1Eno/Mir208atm1.1Eno
Tg(Myh6-Ppp3ca)37Eno/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir208atm1.1Eno mutation (0 available); any Mir208a mutation (2 available)
Tg(Myh6-Ppp3ca)37Eno mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:120908 )
N
• null mice expressing the transgene do not show cardiomyocyte hypertrophy or fibrosis in with expression of this transgene, in contrast to wild-type transgenic mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory