Phenotypes associated with this allele

• Allele Symbol: Atp2b4^tm1Ksch
• Allele Name: targeted mutation 1, Kai Schuh
• Allele ID: MGI:3709898
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp2b4^tm1Ksch/Atp2b4^tm1Ksch	involves: 129P2/OlaHsd * C57BL/6	MGI:3713748

Genotype
MGI:3713748

hm1

• Allelic Composition: Atp2b4^tm1Ksch/Atp2b4^tm1Ksch
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

asthenozoospermia ( J:121031 )

♂ • 68% of sperm from mutant males is immotile, displayed extremely low directed progressive motility (14%), or showed no directed movement (14%), compared to sperm from wild-type (7% immotile, 73% directed movement, 20% no directed motility)

reproductive system

reproductive system phenotype ( J:121031 )

N • homozygous females and heterozygous males are fertile

N • no abnormalities is mating behavior are observed, or erectile dysfunction in homozygous males

N • eggs fertilized in vitro with sperm from homozygous males reached the 2-cell stage after 24 hours, similar to eggs incubated with capacitated wild-type sperm

male infertility ( J:121031 )

♂ • male homozygotes are infertile; no litters are produced when crossed with homozygous or heterozygous females

abnormal sperm physiology ( J:121031 )

♂ • after 60-minute capacitation, sperm shows an intracellular calcium level of 370 nM, compared to a level of 157 nM in wild-type sperm

asthenozoospermia ( J:121031 )

♂ • 68% of sperm from mutant males is immotile, displayed extremely low directed progressive motility (14%), or showed no directed movement (14%), compared to sperm from wild-type (7% immotile, 73% directed movement, 20% no directed motility)

hematopoietic system

increased mean corpuscular hemoglobin concentration ( J:245643 )

♂ • in males between 9 and 13 weeks of age