Phenotypes associated with this allele

• Allele Symbol: Mir155^tm1Rsky
• Allele Name: targeted mutation 1, Klaus Rajewsky
• Allele ID: MGI:3709846
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir155^tm1Rsky/Mir155^tm1Rsky	involves: 129 * C57BL/6	MGI:3809684
hm2	Mir155^tm1Rsky/Mir155^tm1Rsky	involves: 129/Sv * C57BL/6	MGI:3712188

Genotype
MGI:3809684

hm1

• Allelic Composition: Mir155^tm1Rsky/Mir155^tm1Rsky
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal class switch recombination ( J:136224 )

• class switching is impaired compared to in wild-type mice

cellular

chromosomal instability ( J:136224 )

• B cells exhibit a 15-fold increase in reciprocal chromosome translocations between Igh and Myc compared to in Aicda^tm1HonM heterozygotes

hematopoietic system

abnormal class switch recombination ( J:136224 )

• class switching is impaired compared to in wild-type mice

Genotype
MGI:3712188

hm2

• Allelic Composition: Mir155^tm1Rsky/Mir155^tm1Rsky
• Genetic Background: involves: 129/Sv * C57BL/6

immune system

abnormal immune system morphology ( J:121084 )

decreased spleen germinal center number ( J:121084 )

• germinal centers are reduced in number in the spleen compared to control and Gt(ROSA)26Sor^tm1Rsky homozygous mice

decreased spleen germinal center size ( J:121084 )

• germinal centers are smaller in the spleen compared to control and Gt(ROSA)26Sor^tm1Rsky homozygous mice

abnormal gut-associated lymphoid tissue morphology ( J:121084 )

• both Peyer's patches and mesenteric lymph nodes have a decrease in germinal center B cells

abnormal Peyer's patch germinal center morphology ( J:121084 )

• contains less germinal center B Cells

abnormal immune system physiology ( J:121084 )

abnormal humoral immune response ( J:121084 )

• antibody response to NP-CGG is reduced to about one fifth

• however, splenic germinal center B cell numbers are comparable to those in a normal response

abnormal cytokine secretion ( J:121084 )

decreased interferon-gamma secretion ( J:121084 )

• under in vitro conditions that promote does not any differentiation pathway, interferon gamma production is reduced

increased interleukin-10 secretion ( J:121084 )

• under in vitro conditions that promote does not any differentiation pathway IL-10 production is increased

decreased interleukin-4 secretion ( J:121084 )

• under in vitro conditions that promote does not any differentiation pathway, IL-4 production is reduced

decreased tumor necrosis factor secretion ( J:121084 )

• following BCR activation, B cells produce less TNF

hematopoietic system

decreased spleen germinal center number ( J:121084 )

• germinal centers are reduced in number in the spleen compared to control and Gt(ROSA)26Sor^tm1Rsky homozygous mice

decreased spleen germinal center size ( J:121084 )

• germinal centers are smaller in the spleen compared to control and Gt(ROSA)26Sor^tm1Rsky homozygous mice