Analysis Tools
nervous system
| N |
• addtion of leptin to neurons reduces the frequency of spontaneous (s)IPSCs in Pomc1 neurons by about 40%, similar to the inhibition observed in control neurons
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Allele Symbol Allele Name Allele ID |
Tg(Pomc1-hrGFP)1Lowl transgene insertion 1, Bradford B Lowell MGI:3709191 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• addtion of leptin to neurons reduces the frequency of spontaneous (s)IPSCs in Pomc1 neurons by about 40%, similar to the inhibition observed in control neurons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• addition of leptin produces similar inhibition of sIPSCs in neurons to that observed in control preparations
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• addition of leptin fails to reduce the frequency of sIPSCs (spontaneous inhibitory postsynaptic currents) in Pomc1 neurons, while in control slices, the frequency is reduced by about 40%
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• addition of leptin produces similar inhibition of sIPSCs in neurons to that observed in control preparations
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hemizygotes are viable and fertile
• when exposed to UV light, brain tissues show GFP fluorescence in patterns consistent with the endogenous mouse Pomc1 gene
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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