Phenotypes associated with this allele

• Allele Symbol: Ggcx^tm1Dgi
• Allele Name: targeted mutation 1, David Ginsburg
• Allele ID: MGI:3708899
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ggcx^tm1Dgi/Ggcx^tm1Dgi	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3709342
ht2	Ggcx^tm1Dgi/Ggcx^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3709345

Genotype
MGI:3709342

hm1

• Allelic Composition: Ggcx^tm1Dgi/Ggcx^tm1Dgi
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:120784 )

• the rare homozygous pups that are born all die shortly after birth from massive intra-abdominal hemorrhage

lethality throughout fetal growth and development, incomplete penetrance ( J:120784 )

• homozygous embryo numbers are Mendelian at 9.5 dpc (days post coitum), but percentage at 18 dpc is ~half of expected

cardiovascular system

internal hemorrhage ( J:120784 )

• null embryos and neonates have massive intra-abdominal hemorrhages

skeleton

skeleton phenotype ( J:120784 )

N • embryo skeletons show no ectopic calcification

Genotype
MGI:3709345

ht2

• Allelic Composition: Ggcx^tm1Dgi/Ggcx⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:120784 )

N • vitamin K-dependent coagulation factors IX, X, and prothrombin in plasma are indistinguishable from wild-type