Phenotypes associated with this allele

• Allele Symbol: Smad7^tm1Rheu
• Allele Name: targeted mutation 1, Rainer L Heuchel
• Allele ID: MGI:3707713
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smad7^tm1Rheu/Smad7^tm1Rheu	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3709271

Genotype
MGI:3709271

hm1

• Allelic Composition: Smad7^tm1Rheu/Smad7^tm1Rheu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:120714 )

• slight under representation of homozygous offspring at birth

immune system

increased B cell apoptosis ( J:120714 )

• increase in the levels of apoptosis in untreated cultures and in cultures stimulated with TGFB

• however, apoptosis levels are not affected by LSP-treatment

decreased B cell proliferation ( J:120714 )

• lowered proliferation response in 1 and 2 day lymphocyte-specific protein (LSP) stimulated cultures

• however, blocking TGFB completely abolished the difference in proliferation

abnormal class switch recombination ( J:120714 )

• increased activation at the IgA H locus even in the absence of TGFB stimulation

growth/size/body

decreased birth body size ( J:120714 )

• mice are smaller at birth

decreased body weight ( J:120714 )

• at 7 weeks, weight is reduced by 16% (males) to 21% (females) compared to controls

reproductive system

decreased litter size ( J:120714 )

• average litter size is smaller (6.1+/-1.4 pups compared to 9.8+/-2.2 pups)

hematopoietic system

increased B cell apoptosis ( J:120714 )

• increase in the levels of apoptosis in untreated cultures and in cultures stimulated with TGFB

• however, apoptosis levels are not affected by LSP-treatment

decreased B cell proliferation ( J:120714 )

• lowered proliferation response in 1 and 2 day lymphocyte-specific protein (LSP) stimulated cultures

• however, blocking TGFB completely abolished the difference in proliferation

abnormal class switch recombination ( J:120714 )

• increased activation at the IgA H locus even in the absence of TGFB stimulation

cellular

increased B cell apoptosis ( J:120714 )

• increase in the levels of apoptosis in untreated cultures and in cultures stimulated with TGFB

• however, apoptosis levels are not affected by LSP-treatment

decreased B cell proliferation ( J:120714 )

• lowered proliferation response in 1 and 2 day lymphocyte-specific protein (LSP) stimulated cultures

• however, blocking TGFB completely abolished the difference in proliferation