All Phenotypes Mesp2<tm11Ysa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mesp2^tm11Ysa
targeted mutation 11, Yumiko Saga
MGI:3707596

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mesp2^tm11Ysa/Mesp2^tm11Ysa	involves: C57BL/6 * CBA * ICR	MGI:3709543
ht2	Mesp2^tm10Ysa/Mesp2^tm11Ysa	involves: C57BL/6 * CBA * ICR	MGI:3709551
cx3	Mesp1/Mesp2^tm1Ysa/Mesp1⁺ Mesp1/Mesp2^tm1Ysa/Mesp2^tm11Ysa	involves: C57BL/6 * CBA * ICR	MGI:3709549

Allelic Composition	Mesp2^tm11Ysa/Mesp2^tm11Ysa
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp2^tm11Ysa mutation (0 available); any Mesp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal rib morphology ( J:119678 )

• pedicles of the neural arches in the entire vertebra and ribs are fused

abnormal vertebrae morphology ( J:119678 )

• entire vertebra has defects

abnormal thoracic vertebrae morphology ( J:119678 )

abnormal cervical vertebrae morphology ( J:119678 )

abnormal sacral vertebrae morphology ( J:119678 )

fusion of vertebral arches ( J:119678 )

• pedicles of the neural arches in the entire vertebra and ribs are fused

embryo

abnormal somite development ( J:119678 )

• caudalization of somites

Allelic Composition	Mesp2^tm10Ysa/Mesp2^tm11Ysa
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp2^tm10Ysa mutation (1 available); any Mesp2 mutation (30 available)
Mesp2^tm11Ysa mutation (0 available); any Mesp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal vertebrae morphology ( J:119678 )

• vertebral defects extend to the lumbar level in the most posterior vertebra region

fusion of vertebral arches ( J:119678 )

Allelic Composition	Mesp1/Mesp2^tm1Ysa/Mesp1⁺ Mesp1/Mesp2^tm1Ysa/Mesp2^tm11Ysa
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1/Mesp2^tm1Ysa mutation (2 available); any Mesp1 mutation (19 available)
Mesp1/Mesp2^tm1Ysa mutation (0 available); any Mesp2 mutation (30 available)
Mesp2^tm11Ysa mutation (0 available); any Mesp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal vertebrae morphology ( J:119678 )

• caudal vertebra are malformed and a posterior expansion of defects is seen

vertebral fusion ( J:119678 )

• more severe fusion of vertebra than in mice containing Mesp2 disruptions pedicles are fused

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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