Analysis Tools
mortality/aging
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• most embryos die between E9.5 and E10.5
however, Mendelian ratios are found at E9.5
embryonic lethality during organogenesis [MP:0006207] most embryos die between E9.5 and E10.5
however, Mendelian ratios are found at E9.5
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embryo
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• at E8.0, monocilia are absent from the node
• however, node gross morphology is normal
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• embryonic turning is random with 11 of 40 embryos turning leftwards, 11 of 40 turning rightwards and the remaining 18 so severely distorted that turning direction could not be assessed
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• variable severity of delay present at E9.5
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• in severe cases, mice fail to initiate turning by E9.5
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• as shown by bilateral expression of left markers, left-right axis patterning is disrupted
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• at E9.5 embryonic growth is retarded
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• ventral cell specification of the neural tube is lost
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• expression analysis at E9.5 indicates absence of the floor plate
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• at E9.5 mice have an opened brain
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• at E9.5 brain closure and neural tube closure are variable but never complete
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nervous system
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• ventral cell specification of the neural tube is lost
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• expression analysis at E9.5 indicates absence of the floor plate
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• at E9.5 mice have an opened brain
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• at E9.5 brain closure and neural tube closure are variable but never complete
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• at E9.5 there is often an abnormal curvature of the floor of the cranial flexure
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exencephaly
(
J:119664
)
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• at E13.5 in a single surviving embryo the region above the presumed midbrain is open
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• at E9.5 the spinal cord has kinks and displays uneven closure
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cardiovascular system
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• cardiac looping sidedness is sometimes inverted
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• pericardial edema of varying sizes is observed
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limbs/digits/tail
polydactyly
(
J:119664
)
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• at E13.5 in a single surviving embryo, both the fore- and hindlimbs exhibit polydactyly
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craniofacial
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• at E13.5 in a single surviving embryo the maxillary processes fail to fuse and are reduced in length
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growth/size/body
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• at E9.5 embryonic growth is retarded
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vision/eye
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• at E13.5 in a single surviving embryo
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skeleton
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• at E13.5 in a single surviving embryo the maxillary processes fail to fuse and are reduced in length
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homeostasis/metabolism
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• pericardial edema of varying sizes is observed
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cellular
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• at E8.0, monocilia are absent from the node
• however, node gross morphology is normal
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