Phenotypes associated with this allele

• Allele Symbol: Ddb2^tm1Vri
• Allele Name: targeted mutation 1, Harry Vrieling
• Allele ID: MGI:3707217
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddb2^tm1Vri/Ddb2^tm1Vri	involves: 129P2/Ola	MGI:3710081
hm2	Ddb2^tm1Vri/Ddb2^tm1Vri	involves: 129P2/Ola * SKH1	MGI:3710080
ht3	Ddb2^tm1Vri/Ddb2^+	involves: 129P2/Ola * SKH1	MGI:3710082

Genotype
MGI:3710081

hm1

• Allelic Composition: Ddb2^tm1Vri/Ddb2^tm1Vri
• Genetic Background: involves: 129P2/Ola

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

increased sensitivity to skin irradiation ( J:103406 )

• mouse dermal fibroblast cultures, treated with 5 J/m² UV-C radiation, exhibit a delay in repair of pyrimidine(6-4)pyrimidone photoproducts with no repair occurring in the first hour after exposure

Genotype
MGI:3710080

hm2

• Allelic Composition: Ddb2^tm1Vri/Ddb2^tm1Vri
• Genetic Background: involves: 129P2/Ola * SKH1

neoplasm

increased squamous cell carcinoma incidence ( J:103406 )

• 50% of mice develop squamous cell carcinomas larger than 1mm by week 10 and yields of squamous cell carcinomas larger than 1 and 2 mm are increased following a daily dose of 250 J/m²

integument

increased sensitivity to skin irradiation ( J:120007 )

• mice exhibit an increase in cyclobutane pyrimidine dimers following 40 days of daily irradiation with a UV dose of 70 J/m² (0.14 MED)

• however, no hyperplasia is observed

Genotype
MGI:3710082

ht3

• Allelic Composition: Ddb2^tm1Vri/Ddb2⁺
• Genetic Background: involves: 129P2/Ola * SKH1

neoplasm

increased squamous cell carcinoma incidence ( J:103406 )

• 50% and 100% of mice develop squamous cell carcinomas at weeks 11 and 15, respectively, whereas wild-type mice develop similar percentages at weeks 16 and 20, respectively, following a daily dose of 250 J/m²

• yields of squamous cell carcinomas larger than 1mm and 2mm are increased following a daily dose of 250 J/m²