Analysis Tools
reproductive system
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• mono- or multinucleated large cells are sometimes seen
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• at P35, about 2/3 of mice display abnormal testes morphology of variable severity
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• in some cases, mice have a reduction in the number of spermatocytes and lack spermatids and mature spermatozoa in the seminiferous tubules
• mono- or multinucleated large cells are sometimes seen
• however, sertoli cells and spermatogonia are morphologically and numerically normal
• at P15, degenerating pachytene stage spermatocytes, increased numbers of apoptotic cells, and vacuoles in the luminal region are seen
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• the frequency of early pachytene spermatocytes is 66% compared to 37% in wild-type
• some mice have a reduction in the number of spermatocytes
• starting at P15 apoptosis progressively removes post-mitotic spermatocytes during the first wave of spermatogenesis
• spermatocytes are incompletely depleted by late pachytene when chromatin remodeling takes place
• however, chromosome pairing and synapses of homologous chromosomes is normal
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azoospermia
(
J:119909
)
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• in some cases mice lack spermatids and mature spermatozoa in the seminiferous tubules
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• block in spermatogenesis during the pachytene stage with abnormal chromatin modifications of the XY body
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• about half of the males are sterile
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skeleton
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• 5% of mice have detachment of the seventh rib from the sternum
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• 49% of mice have an additional rib on C7
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• 10% of mice have C1 to C2 fusions
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• variable posterior transformations are observed
• 13% of mice have posterior transformations involving the sacroiliac joint
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• an ectopic bone in the craniodorsal region of C1 or ectopic arch associated with the occipital bone is seen in 5% of mice
• posterior transformation of C7 in 49% of mice
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endocrine/exocrine glands
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• at P35, about 2/3 of mice display abnormal testes morphology of variable severity
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|
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• in some cases, mice have a reduction in the number of spermatocytes and lack spermatids and mature spermatozoa in the seminiferous tubules
• mono- or multinucleated large cells are sometimes seen
• however, sertoli cells and spermatogonia are morphologically and numerically normal
• at P15, degenerating pachytene stage spermatocytes, increased numbers of apoptotic cells, and vacuoles in the luminal region are seen
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cellular
azoospermia
(
J:119909
)
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• in some cases mice lack spermatids and mature spermatozoa in the seminiferous tubules
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• mono- or multinucleated large cells are sometimes seen
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• MEFs enter senescence earlier compared to wild-type cells
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