Phenotypes associated with this allele

• Allele Symbol: Hectd1^Gt(XC266)Byg
• Allele Name: gene trap XC266, BayGenomics
• Allele ID: MGI:3706565
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hectd1^Gt(XC266)Byg/Hectd1^Gt(XC266)Byg	involves: 129P2/OlaHsd	MGI:3707222
ht2	Hectd1^Gt(XC266)Byg/Hectd1^+	involves: 129P2/OlaHsd	MGI:3707233
ht3	Hectd1^Gt(XC266)Byg/Hectd1^opm	involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6	MGI:3707220

Genotype
MGI:3707222

hm1

• Allelic Composition: Hectd1^Gt(XC266)Byg/Hectd1^Gt(XC266)Byg
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal neurocranium morphology ( J:122594 )

• authors state that the phenotype observed is identical to that of Hectd1^opm homozygotes

absent temporal bone petrous part ( J:122594 )

abnormal frontal bone morphology ( J:122594 )

absent interparietal bone ( J:122594 )

absent exoccipital bone ( J:122594 )

abnormal parietal bone morphology ( J:122594 )

abnormal craniofacial development ( J:122594 )

• authors state that the phenotype observed is identical to that of Hectd1^opm homozygotes

vision/eye

abnormal eye morphology ( J:122594 )

• ocular dysplasia

abnormal eye distance/ position ( J:122594 )

microphthalmia ( J:122594 )

embryo

abnormal embryonic tissue morphology ( J:122594 )

• Authors state that the phenotype observed is identical to that of Hectd1^opm homozygotes

abnormal neural fold elevation formation ( J:122594 )

nervous system

exencephaly ( J:122594 )

• Authors state that the phenotype observed is identical to that of Hectd1^opm homozygotes

skeleton

abnormal neurocranium morphology ( J:122594 )

• authors state that the phenotype observed is identical to that of Hectd1^opm homozygotes

absent temporal bone petrous part ( J:122594 )

abnormal frontal bone morphology ( J:122594 )

absent interparietal bone ( J:122594 )

absent exoccipital bone ( J:122594 )

abnormal parietal bone morphology ( J:122594 )

growth/size/body

abnormal frontal bone morphology ( J:122594 )

Genotype
MGI:3707233

ht2

• Allelic Composition: Hectd1^Gt(XC266)Byg/Hectd1⁺
• Genetic Background: involves: 129P2/OlaHsd

nervous system

exencephaly ( J:122594 )

• between E9.5 and 12.5, 20% of embryos exhibit cranial neural tube closure defects

Genotype
MGI:3707220

ht3

• Allelic Composition: Hectd1^Gt(XC266)Byg/Hectd1^opm
• Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

nervous system

exencephaly ( J:122594 )

• at E9.5, embryos exhibit cranial neural tube closure defects from forebrain to hindbrain identical to Hectd1^opm homozygotes