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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
P4ha1tm1Jomy
targeted mutation 1, Johanna Myllyharju
MGI:3706369
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
P4ha1tm1Jomy/P4ha1tm1Jomy involves: 129/Sv * C57BL MGI:3707714


Genotype
MGI:3707714
hm1
Allelic
Composition
P4ha1tm1Jomy/P4ha1tm1Jomy
Genetic
Background
involves: 129/Sv * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P4ha1tm1Jomy mutation (1 available); any P4ha1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• development is delayed after E9.0
• at E10.5 embryos are small and fragile compared to wild-type
• at E10.5 in the developing limb bud, mesenchymal cell density is reduced, cell-cell contacts are rare, and cells have fewer filopodia

growth/size/body
• development is delayed after E9.0
• at E10.5 embryos are small and fragile compared to wild-type

cardiovascular system
• at E10.5 capillary walls are frequently ruptured and usually empty of red blood cells
• however, capillary density is similar to wild-type

cellular
• at E10.5, the endoplasmic reticulum is dilated
• mice lack a distinct basal membrane structure and assembly of insoluble supramolecular collagen structures is impaired

integument

limbs/digits/tail
• at E10.5 in the developing limb bud, mesenchymal cell density is reduced, cell-cell contacts are rare, and cells have fewer filopodia





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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory