Phenotypes associated with this allele

• Allele Symbol: Trim54^tm1Eno
• Allele Name: targeted mutation 1, Eric N Olson
• Allele ID: MGI:3706252
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim54^tm1Eno/Trim54^tm1Eno	B6.Cg-Trim54^tm1Eno	MGI:3707316

Genotype
MGI:3707316

hm1

• Allelic Composition: Trim54^tm1Eno/Trim54^tm1Eno
• Genetic Background: B6.Cg-Trim54^tm1Eno

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:120068 )

• after surgically-induced myocardial infarction (MI)), mutants show significant mortality (10/13) within 5 days of surgery compared to wild-type (4/27); 10/13 mice die as result of cardiac rupture compared to 0 wild-type

cardiovascular system

abnormal heart morphology ( J:120068 )

• 77% of mutants die of cardiac rupture within 5 days of induced MI

myocardial fiber degeneration ( J:120068 )

• mutant hearts contain degenerative myofibers between infarcted and noninfarcted myocardium

cardiac hypertrophy ( J:120068 )

• after 7 days of isoproterenol infusion, mutants show a 32% increase in cardiac mass compared to a 45% increase in wild-type

abnormal heart left ventricle morphology ( J:120068 )

• mice have increased left ventricular end-systolic and end-diastolic diameters compared to wild-type mice after MI surgery

• mutants show a greater increase in left ventricular end-systolic and end-diastolic diameters compared to wild-type after isoproterenol infusion

decreased heart left ventricle posterior wall thickness ( J:120068 )

• reduction in thickness of left ventricle posterior wall is observed after MI surgery

dilated cardiomyopathy ( J:120068 )

• phenotype observed after MI surgery

hemorrhage ( J:120068 )

• intramural hemorrhage in the infarcted area is seen in mutants but not wild-type

abnormal cardiac muscle contractility ( J:120068 )

• end-systolic and end-diastolic diameters result in decrease in fractional shortening of muscle fibers in mutants compared to wild-type mice

• reduction in fractional shortening is observed in mutants after isoproterenol infusion compared to wild-type

increased cardiomyocyte apoptosis ( J:120068 )

• after MI, mutants have 3-fold greater levels of apoptosis in the periinfarct zone compared to wild-type littermates

• after isoproterenol infusion, mutants show a 2-fold greater level of apoptosis relative to treated wild-type

muscle

myocardial fiber degeneration ( J:120068 )

• mutant hearts contain degenerative myofibers between infarcted and noninfarcted myocardium

dilated cardiomyopathy ( J:120068 )

• phenotype observed after MI surgery

abnormal cardiac muscle contractility ( J:120068 )

• end-systolic and end-diastolic diameters result in decrease in fractional shortening of muscle fibers in mutants compared to wild-type mice

• reduction in fractional shortening is observed in mutants after isoproterenol infusion compared to wild-type

increased cardiomyocyte apoptosis ( J:120068 )

• after MI, mutants have 3-fold greater levels of apoptosis in the periinfarct zone compared to wild-type littermates

• after isoproterenol infusion, mutants show a 2-fold greater level of apoptosis relative to treated wild-type

abnormal sarcomere morphology ( J:120068 )

• there is a significant distance between Z-discs, but this did not result in significant abnormalities in fractional shortening

behavior/neurological

lethargy ( J:120068 )

• 2-3 days after surgically-induced MI, mutants appear lethargic, phenotypically similar to heart failure

cellular

increased cardiomyocyte apoptosis ( J:120068 )

• after MI, mutants have 3-fold greater levels of apoptosis in the periinfarct zone compared to wild-type littermates

• after isoproterenol infusion, mutants show a 2-fold greater level of apoptosis relative to treated wild-type

growth/size/body

cardiac hypertrophy ( J:120068 )

• after 7 days of isoproterenol infusion, mutants show a 32% increase in cardiac mass compared to a 45% increase in wild-type