Phenotypes associated with this allele

• Allele Symbol: Sicd1^C57BL/6J
• Allele Name: C57BL/6J
• Allele ID: MGI:3706137
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sicd1^C57BL/6J/Sicd1^C57BL/6J	FVB.B6-(D18Mit129-D18Mit25)	MGI:3716504
hm2	Sicd1^C57BL/6J/Sicd1^C57BL/6J	FVB.B6-(D18Mit141-D18Mit25)	MGI:3716503
hm3	Sicd1^C57BL/6J/Sicd1^C57BL/6J	FVB.B6-(D18Mit186-D18Mit4)	MGI:3706140

Genotype
MGI:3716504

hm1

• Allelic Composition: Sicd1^C57BL/6J/Sicd1^C57BL/6J
• Genetic Background: FVB.B6-(D18Mit129-D18Mit25)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

loss of hippocampal neurons ( J:122922 )

• 75% reduction in kainic acid-induced hippocampal cell death, especially in area CA3, compared to FVB/NJ

Genotype
MGI:3716503

hm2

• Allelic Composition: Sicd1^C57BL/6J/Sicd1^C57BL/6J
• Genetic Background: FVB.B6-(D18Mit141-D18Mit25)

nervous system

increased susceptibility to pharmacologically induced seizures ( J:122922 )

• decreased seizure latency induced by kainic acid

loss of hippocampal neurons ( J:122922 )

• resistance to neuronal cell death, especially in area CA3, after kainic acid-induced seizure

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:122922 )

• decreased seizure latency induced by kainic acid

Genotype
MGI:3706140

hm3

• Allelic Composition: Sicd1^C57BL/6J/Sicd1^C57BL/6J
• Genetic Background: FVB.B6-(D18Mit186-D18Mit4)

nervous system

loss of hippocampal neurons ( J:119634 )

• resistance to hippocampal cell death after kainic acid-induced seizure