Phenotypes associated with this allele

• Allele Symbol: Dok7^tm1Yyam
• Allele Name: targeted mutation 1, Yuji Yamanashi
• Allele ID: MGI:3702943
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dok7^tm1Yyam/Dok7^tm1Yyam	involves: 129P2/OlaHsd * C57BL/6	MGI:3704003

Genotype
MGI:3704003

hm1

• Allelic Composition: Dok7^tm1Yyam/Dok7^tm1Yyam
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:110011 )

• homozygotes die shortly after birth

behavior/neurological

akinesia ( J:110011 )

• homozygotes are immobile at birth

nervous system

abnormal innervation pattern to muscle ( J:110011 )

• failure to breathe indicates lack of neuromuscular transmission in skeletal muscles

abnormal neuromuscular synapse morphology ( J:110011 )

• there are no detectable acetylcholine receptor clusters in the endplate area of the diaphragm muscle in mutants at E14.5 or E18.5

respiratory system

abnormal pulmonary alveolus morphology ( J:110011 )