Phenotypes associated with this allele

• Allele Symbol: Klhl3⁺
• Allele Name: wild type
• Allele ID: MGI:3702653
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Klhl3^tm1.1Esoh/Klhl3^+	involves: C57BL/6	MGI:5646380
ht2	Klhl3^tm1.1Slin/Klhl3^+	Not Specified	MGI:6393411

Genotype
MGI:5646380

ht1

• Allelic Composition: Klhl3^tm1.1Esoh/Klhl3⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

salt-sensitive hypertension ( J:214330 )

• significantly greater increase in systolic blood pressure on a high salt diet

• blood pressure on a normal salt diet is similar to controls

homeostasis/metabolism

hyperkalemia ( J:214330 )

metabolic acidosis ( J:214330 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pseudohypoaldosteronism		DOID:4479		J:214330

Genotype
MGI:6393411

ht2

• Allelic Composition: Klhl3^tm1.1Slin/Klhl3⁺
• Genetic Background: Not Specified

cardiovascular system

increased systemic arterial systolic blood pressure ( J:284284 )

renal/urinary system

decreased urine potassium level ( J:284284 )

• mice show decreased fractional excretion of potassium

homeostasis/metabolism

acidemia ( J:284284 )

decreased circulating bicarbonate level ( J:284284 )

increased circulating aldosterone level ( J:284284 )

hyperkalemia ( J:284284 )

increased circulating chloride level ( J:284284 )

decreased urine potassium level ( J:284284 )

• mice show decreased fractional excretion of potassium

metabolic acidosis ( J:284284 )

• hyperchloremic metabolic acidosis

decreased renin activity ( J:284284 )

• secondary hyporeninemia

abnormal physiological response to xenobiotic ( J:284284 )

• mice show an increased diuretic response to hydrochlorothiazide (NCC inhibitor), showing increased fractional excretion of sodium, potassium and chloride

• mice show a blunted diuretic response to treatment with furosemide (NKCC2 inhibitor), showing decreased fractional excretion of sodium, potassium and chloride

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pseudohypoaldosteronism		DOID:4479		J:284284