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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Anpeptm1Sid
targeted mutation 1, Richard L Sidman
MGI:3702506
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Anpeptm1Sid/Anpeptm1Sid involves: 129S/SvEv * C57BL/6 MGI:3703749
ht2
 		Anpeptm1Sid/Anpep+ involves: 129S/SvEv * C57BL/6 MGI:3703750


Genotype
MGI:3703749
hm1
Allelic
Composition		 Anpeptm1Sid/Anpeptm1Sid
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anpeptm1Sid mutation (0 available); any Anpep mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
pathological neovascularization ( J:119474 )
• reduced vessel growth into implanted gelfoam sponges in response to VEGF, basic FGF and TGF-alpha stimulation
retina neovascularization ( J:119474 )
• reduced formation of new blood vessels on the retinal inner surface following hypoxic conditions (75% oxygen between P7-12)

reproductive system
reproductive system phenotype ( J:119474 )
N
• fertile with normal litter sizes

vision/eye
retina neovascularization ( J:119474 )
• reduced formation of new blood vessels on the retinal inner surface following hypoxic conditions (75% oxygen between P7-12)




Genotype
MGI:3703750
ht2
Allelic
Composition		 Anpeptm1Sid/Anpep+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anpeptm1Sid mutation (0 available); any Anpep mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
retina neovascularization ( J:119474 )
• intermediate reduction, between wild-type and homozygous mice, in the formation of new blood vessels on the retinal inner surface following hypoxic conditions (75% oxygen between P7-P12)

vision/eye
retina neovascularization ( J:119474 )
• intermediate reduction, between wild-type and homozygous mice, in the formation of new blood vessels on the retinal inner surface following hypoxic conditions (75% oxygen between P7-P12)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory