All Phenotypes Tg(CAG-cat,-Notch1)1Ysa MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mesp1^tm2(cre)Ysa/Mesp1⁺ Rbpj^tm1Hon/Rbpj^tm1Hon Tg(CAG-cat,-Notch1)1Ysa/0	involves: 129P2/OlaHsd * C3H * C57BL/6 * CBA	MGI:3808717
cn2	Hey1^tm1Kkb/Hey1^tm1Kkb Mesp1^tm2(cre)Ysa/Mesp1⁺ Tg(CAG-cat,-Notch1)1Ysa/0	involves: 129S7/SvEvBrd * C3H * C57BL/6 * CBA	MGI:3702490
cn3	Mesp1^tm2(cre)Ysa/Mesp1⁺ Tg(CAG-cat,-Notch1)1Ysa/0	involves: C3H * C57BL/6 * CBA	MGI:3702469
cn4	Mesp1^tm2(cre)Ysa/Mesp1⁺ Pofut1^tm1Ysa/Pofut1^tm1Ysa Tg(CAG-cat,-Notch1)1Ysa/0	involves: C3H * C57BL/6 * CBA * SJL	MGI:3808715

Allelic Composition	Mesp1^tm2(cre)Ysa/Mesp1⁺ Rbpj^tm1Hon/Rbpj^tm1Hon Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background	involves: 129P2/OlaHsd * C3H * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1^tm2(cre)Ysa mutation (1 available); any Mesp1 mutation (17 available)
Rbpj^tm1Hon mutation (2 available); any Rbpj mutation (193 available)
Tg(CAG-cat,-Notch1)1Ysa mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart morphology ( J:139209 )

• defects in heart morphology and development are unaffected by the presence of the transgene

abnormal heart development ( J:139209 )

• defects in heart morphology and development are unaffected by the presence of the transgene

Allelic Composition	Hey1^tm1Kkb/Hey1^tm1Kkb Mesp1^tm2(cre)Ysa/Mesp1⁺ Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background	involves: 129S7/SvEvBrd * C3H * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey1^tm1Kkb mutation (0 available); any Hey1 mutation (17 available)
Mesp1^tm2(cre)Ysa mutation (1 available); any Mesp1 mutation (17 available)
Tg(CAG-cat,-Notch1)1Ysa mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal myocardial trabeculae morphology ( J:108444 )

• mutants exhibit impaired ventricular trabeculation, however there is much less trabeculation of the atrioventricular myocardium compared with mutants that are not null for Hey1

abnormal atrioventricular cushion morphology ( J:108444 )

• mutants exhibit ectopic appearance of cell masses in the atrioventricular cushion

abnormal interventricular septum morphology ( J:108444 )

• the interventricular septum is shifted to the right side

muscle

abnormal myocardial trabeculae morphology ( J:108444 )

• mutants exhibit impaired ventricular trabeculation, however there is much less trabeculation of the atrioventricular myocardium compared with mutants that are not null for Hey1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:108444 )

• embryos do not develop beyond E10.5 and die before E11.5

cardiovascular system

abnormal myocardium layer morphology ( J:108444 )

• exhibit impaired myocardium of the atrioventricular canal

abnormal myocardial fiber morphology ( J:108444 )

• cardiac myofibrils are poorly formed

• mutants exhibit impaired ventricular myocardial differentiation

• the atrioventricular myocardial wall shows evidence of trabeculation

abnormal heart development ( J:108444 )

abnormal atrioventricular cushion morphology ( J:108444 )

• exhibit ectopic appearance of cell masses in the atrioventricular cushion

abnormal heart shape ( J:108444 )

• hearts are deformed in shape with a rough surface morphology

enlarged heart ( J:139209 )

abnormal heart ventricle morphology ( J:108444 )

abnormal trabecula carnea morphology ( J:108444 )

• exhibit abnormal accumulation of trabecular cells in the ventricular wall near the compact layer

abnormal interventricular septum morphology ( J:108444 )

• the interventricular septum is shifted to the right side

dilated heart left ventricle ( J:108444 )

• the left ventricle is expanded

decreased heart right ventricle size ( J:108444 )

• the right ventricle is reduced in size

muscle

abnormal myocardium layer morphology ( J:108444 )

• exhibit impaired myocardium of the atrioventricular canal

abnormal myocardial fiber morphology ( J:108444 )

• cardiac myofibrils are poorly formed

• mutants exhibit impaired ventricular myocardial differentiation

• the atrioventricular myocardial wall shows evidence of trabeculation

abnormal trabecula carnea morphology ( J:108444 )

• exhibit abnormal accumulation of trabecular cells in the ventricular wall near the compact layer

abnormal sarcomere morphology ( J:108444 )

• cardiac myofibrils show an unclear sarcomere structure

growth/size/body

enlarged heart ( J:139209 )

Allelic Composition	Mesp1^tm2(cre)Ysa/Mesp1⁺ Pofut1^tm1Ysa/Pofut1^tm1Ysa Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background	involves: C3H * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1^tm2(cre)Ysa mutation (1 available); any Mesp1 mutation (17 available)
Pofut1^tm1Ysa mutation (0 available); any Pofut1 mutation (22 available)
Tg(CAG-cat,-Notch1)1Ysa mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart development ( J:139209 )

• trabecular layer defects observed in Pofut1^tm1Ysa/Pofut1^tm1Ysa Mesp1^tm2(cre)Ysa/Mesp1⁺ mice are partially rescued

enlarged heart ( J:139209 )

growth/size/body

enlarged heart ( J:139209 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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