All Phenotypes Col1a1<tm2(tetO-Pou5f1)Jae> MGI Mouse

premature death ( J:98920 )

• mice with doxycycline-induced ectopic Oct4 expression become morbid after 3-5 days of treatment and usually die after 5-10 days of treatment

• however, if doxycycline treatment is stopped after 5 days mice completely recover

abnormal intestinal epithelium morphology ( J:98920 )

• after doxycline treatment, dysplastic cells are found in the entire epithelium; cells have structural and cytological dysplasia which mimics adenocarcinoma

abnormal small intestine morphology ( J:98920 )

• the proximal part of the small intestine is most severely affected by doxycycline treatment with abnormal cells often almost obstructing the lumen

• after 5 days of doxycycline treatment, proliferative zone expands; postmitotic, differentiated cells lining the villus are replaced

• upon cessation of treatment, cells migrate to final destinations and differentiate resulting in restoration of normal morphology

abnormal forestomach morphology ( J:98920 )

• in doxycycline treated mice, cells in the forestomach show a marked atypia and increased mitotic activity

abnormal stomach mucosa morphology ( J:98920 )

• pyloric mucosa contains lesions resembling high grade-dysplasia in doxycycline treated mice

abnormal intermediate gastric gland morphology ( J:98920 )

• hyperplastic fundic glands are seen in doxycycline treated mice

abnormal stomach epithelium morphology ( J:98920 )

• in doxycycline treated mice, forestomach epithelium is thickened and stomach shows lack of differentiation into granular and cornified cell layers compared to control mice

• the thickened epithelium consists of atypical cells with enlarged nuclei and prominent nucleoli

abnormal stomach glandular epithelium morphology ( J:98920 )

• after doxycycline treatment, mice display severe dysplasia and increased proliferation

stomach epithelial hyperplasia ( J:98920 )

• cells show atypia and increased mitotic activity throughout the squamous epithelial layer in doxycycline treated mice

dehydration ( J:98920 )

• after 3-5 days of doxycycline treatment, animals display severe dehydration

abnormal cell proliferation ( J:98920 )

• abnormal cell proliferation is observed in several organs after 2 days of Oct4-induction

• however, complete reversion is seen with withdrawal of doxycycline treatment

lethargy ( J:98920 )

• animals become lethargic with doxycycline treatment within 3-5 days

thymus atrophy ( J:98920 )

• atrophy and absence of CD4, CD8 double positive cells in doxycycline treated mice

spleen atrophy ( J:98920 )

• in doxycycline treated mice

thymus atrophy ( J:98920 )

• atrophy and absence of CD4, CD8 double positive cells in doxycycline treated mice

spleen atrophy ( J:98920 )

• in doxycycline treated mice

increased skin tumor incidence ( J:98920 )

• in doxycycline treated mice, tumors originating from the outer-root-sheath progenitors and invading the subcutaneous layer are seen

abnormal hair follicle morphology ( J:98920 )

• increased numbers of immature cells in the hair follicles of the skin are seen after 5-10 days of doxycycline

abnormal epidermal layer morphology ( J:98920 )

• after 5-10 days of doxycycline treatment, mice show mild to moderate epidermal dysplasia with a decrease in differentiation in dysplastic cells

increased skin tumor incidence ( J:98920 )

• in doxycycline treated mice, tumors originating from the outer-root-sheath progenitors and invading the subcutaneous layer are seen

abnormal intermediate gastric gland morphology ( J:98920 )

• hyperplastic fundic glands are seen in doxycycline treated mice

thymus atrophy ( J:98920 )

• atrophy and absence of CD4, CD8 double positive cells in doxycycline treated mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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