Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp2tm7.1(mespb)Ysa mutation
(1 available);
any
Mesp2 mutation
(30 available)
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mortality/aging
N |
• unlike mice homozygous for an Mesp2 null allele, these mice are viable and fertile
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limbs/digits/tail
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp2tm1Ysa mutation
(0 available);
any
Mesp2 mutation
(30 available)
Mesp2tm7.1(mespb)Ysa mutation
(1 available);
any
Mesp2 mutation
(30 available)
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mortality/aging
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• die shortly after birth
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embryo
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• at E11.5 in embryonic tails, initial segmental borders form; however, segregation is incomplete and somitic cells remain between the newly formed somites
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• expression analysis indicates impaired formation of rostral-caudal polarity in the anterior presomitic mesoderm
• severity of impairment is less than in homozygous null mice or in mice where the neo cassette had not been removed
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• maintenance of segmental borders is impaired
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skeleton
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• fusion of both the ribs and vertebral column, although not as severe as in homozygous null mice or as in mice where the neo cassette had not been removed
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• fusion of both the ribs and vertebral column, although not as severe as in homozygous null mice or as in mice where the neo cassette had not been removed
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