Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mesp2tm7.1(mespb)Ysa targeted mutation 7.1, Yumiko Saga MGI:3702019 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike mice homozygous for an Mesp2 null allele, these mice are viable and fertile
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die shortly after birth
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• at E11.5 in embryonic tails, initial segmental borders form; however, segregation is incomplete and somitic cells remain between the newly formed somites
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• expression analysis indicates impaired formation of rostral-caudal polarity in the anterior presomitic mesoderm
• severity of impairment is less than in homozygous null mice or in mice where the neo cassette had not been removed
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• maintenance of segmental borders is impaired
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• fusion of both the ribs and vertebral column, although not as severe as in homozygous null mice or as in mice where the neo cassette had not been removed
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• fusion of both the ribs and vertebral column, although not as severe as in homozygous null mice or as in mice where the neo cassette had not been removed
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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