Phenotypes associated with this allele

• Allele Symbol: Mesp2^{tm7.1(mespb)Ysa}
• Allele Name: targeted mutation 7.1, Yumiko Saga
• Allele ID: MGI:3702019
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mesp2^tm7.1(mespb)Ysa/Mesp2^tm7.1(mespb)Ysa	involves: C57BL/6 * CBA	MGI:3702283
ht2	Mesp2^tm1Ysa/Mesp2^tm7.1(mespb)Ysa	involves: C57BL/6 * CBA	MGI:3702284

Genotype
MGI:3702283

hm1

• Allelic Composition: Mesp2^{tm7.1(mespb)Ysa}/Mesp2^{tm7.1(mespb)Ysa}
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:75945 )

N • unlike mice homozygous for an Mesp2 null allele, these mice are viable and fertile

limbs/digits/tail

kinked tail ( J:75945 )

Genotype
MGI:3702284

ht2

• Allelic Composition: Mesp2^tm1Ysa/Mesp2^{tm7.1(mespb)Ysa}
• Genetic Background: involves: C57BL/6 * CBA

mortality/aging

neonatal lethality, complete penetrance ( J:75945 )

• die shortly after birth

embryo

abnormal somite development ( J:75945 )

• at E11.5 in embryonic tails, initial segmental borders form; however, segregation is incomplete and somitic cells remain between the newly formed somites

abnormal rostral-caudal patterning of the somites ( J:75945 )

• expression analysis indicates impaired formation of rostral-caudal polarity in the anterior presomitic mesoderm

• severity of impairment is less than in homozygous null mice or in mice where the neo cassette had not been removed

abnormal somite border morphology ( J:75945 )

• maintenance of segmental borders is impaired

skeleton

rib fusion ( J:75945 )

• fusion of both the ribs and vertebral column, although not as severe as in homozygous null mice or as in mice where the neo cassette had not been removed

vertebral fusion ( J:75945 )

• fusion of both the ribs and vertebral column, although not as severe as in homozygous null mice or as in mice where the neo cassette had not been removed