All Phenotypes Sox2<tm1Vep> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sox2^tm1Vep
targeted mutation 1, Vasso Episkopou
MGI:3701964

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Sox2^tm1Vep/Sox2⁺	Not Specified	MGI:3702611
cx2	Sox1^tm1Vep/Sox1^tm2Vep Sox2^tm1Vep/Sox2⁺	involves: 129S/SvEv	MGI:3702615
cx3	Sox1^tm1Vep/Sox1^tm1Vep Sox2^tm1Vep/Sox2⁺	involves: 129S/SvEv	MGI:3702617

Allelic Composition	Sox2^tm1Vep/Sox2⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2^tm1Vep mutation (0 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:99610 )

• mice are viable and fertile, with no phenotypic abnormalities; overexpression of Sox1 does not cause any abnormalities

Allelic Composition	Sox1^tm1Vep/Sox1^tm2Vep Sox2^tm1Vep/Sox2⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox1^tm1Vep mutation (0 available); any Sox1 mutation (13 available)
Sox1^tm2Vep mutation (0 available); any Sox1 mutation (13 available)
Sox2^tm1Vep mutation (0 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:99610 )

• lethality associated with seizures is observed around weaning and is increased relative to Sox1-null mice

behavior/neurological

seizures ( J:99610 )

nervous system

seizures ( J:99610 )

abnormal olfactory cortex morphology ( J:99610 )

• embryos do not develop the olfactory tubercle (OT)

• at P10, OT neurons are detected in striatal mantle, but not in ventral striatum

vision/eye

microphthalmia ( J:99610 )

• mice are born with small eyes

Allelic Composition	Sox1^tm1Vep/Sox1^tm1Vep Sox2^tm1Vep/Sox2⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox1^tm1Vep mutation (0 available); any Sox1 mutation (13 available)
Sox2^tm1Vep mutation (0 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory cortex morphology ( J:99610 )

• olfactory tubercle (OT) region is compacted in absence of many Sox1 neurons

• neurons expressing Sox1 from the Sox2 locus migrate to the OT in absence of endogenous Sox1 expression; striatal bridges form

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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