Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox1tm2Vep mutation
(0 available);
any
Sox1 mutation
(13 available)
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mortality/aging
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• homozygotes show same phenotype as Sox1tm1Vep homozygotes
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behavior/neurological
nervous system
vision/eye
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox1tm1Vep mutation
(0 available);
any
Sox1 mutation
(13 available)
Sox1tm2Vep mutation
(0 available);
any
Sox1 mutation
(13 available)
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nervous system
N |
• generation and patterning of lateral ganglionic eminence (LGE) precursors is normal in mutants
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• early- and late-born neurons fail to migrate to appropriate positions to form ventral striatum
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• between E13 and 16, striatal mantle is more densely populated by proliferating precursors compared to wild-type
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• migration or differentiation of ventral striatum (VS) neurons is disturbed in mutants
• at E13 to birth, the striatal bridges are absent
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• staining for the markers Brn5 and Robo at E13 reveals a neural differentiation defect restricted in the region of the nucleus accumbens and olfactory tubercle (OT), and not the rest of the striatum
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• at E13 to birth, the striatal bridges and the olfactory tubercule (OT) layers are absent
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cellular
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• early- and late-born neurons fail to migrate to appropriate positions to form ventral striatum
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox1tm1Vep mutation
(0 available);
any
Sox1 mutation
(13 available)
Sox1tm2Vep mutation
(0 available);
any
Sox1 mutation
(13 available)
Sox2tm1Vep mutation
(0 available);
any
Sox2 mutation
(56 available)
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mortality/aging
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• lethality associated with seizures is observed around weaning and is increased relative to Sox1-null mice
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behavior/neurological
nervous system
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• embryos do not develop the olfactory tubercle (OT)
• at P10, OT neurons are detected in striatal mantle, but not in ventral striatum
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vision/eye
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• mice are born with small eyes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Enpp2tm1.1Vart mutation
(1 available);
any
Enpp2 mutation
(77 available)
Sox1tm2Vep mutation
(0 available);
any
Sox1 mutation
(13 available)
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embryo
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• at E9.5, head folds are asymmetric unlike in wild-type mice
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nervous system
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• at E9.5, head folds are asymmetric unlike in wild-type mice
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