Phenotypes associated with this allele

• Allele Symbol: Gapdh^M6Neu
• Allele Name: mutation 6, Neuherberg
• Allele ID: MGI:3701515
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gapdh^M6Neu/Gapdh^M6Neu	C3.Cg-Gapdh^M6Neu	MGI:3808738
ht2	Gapdh^M6Neu/Gapdh^+	C3.Cg-Gapdh^M6Neu	MGI:3808739

Genotype
MGI:3808738

hm1

• Allelic Composition: Gapdh^M6Neu/Gapdh^M6Neu
• Genetic Background: C3.Cg-Gapdh^M6Neu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:126359 )

• homozygous lethal

cardiovascular system

cardiovascular system phenotype ( J:126359 )

N • heart somatic index does not differ significantly from wild-type or heterozygous littermates

growth/size/body

growth/size/body region phenotype ( J:126359 )

N • body weight does not differ significantly from wild-type or heterozygous littermates

hematopoietic system

hematopoietic system phenotype ( J:126359 )

N • spleen somatic index does not differ significantly from wild-type or heterozygous littermates

abnormal hematocrit ( J:126359 )

• significant reduction compared to wild-type

decreased hemoglobin content ( J:126359 )

• significant reduction compared to wild-type

liver/biliary system

liver/biliary system phenotype ( J:126359 )

N • liver somatic index does not differ significantly from wild-type or heterozygous littermates

renal/urinary system

renal/urinary system phenotype ( J:126359 )

N • kidney somatic index does not differ significantly from wild-type or heterozygous littermates

Genotype
MGI:3808739

ht2

• Allelic Composition: Gapdh^M6Neu/Gapdh⁺
• Genetic Background: C3.Cg-Gapdh^M6Neu

mortality/aging

preweaning lethality, incomplete penetrance ( J:126359 )

• number of heterzygous offspring is reduced

homeostasis/metabolism

decreased glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity ( J:126359 )

• Gapdh activity is approximately 50-55% of wild-type levels