About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ticam1tm1Tsse
targeted mutation 1, Tsukasa Seya
MGI:3701472
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ticam1tm1Tsse/Ticam1tm1Tsse B6.129-Ticam1tm1Tsse MGI:3703444
cx2
 		Ticam1tm1Tsse/Ticam1tm1Tsse
Tg(PVR)1Kkst/0 		involves: 129 * C57BL/6 * ICR MGI:5558901


Genotype
MGI:3703444
hm1
Allelic
Composition		 Ticam1tm1Tsse/Ticam1tm1Tsse
Genetic
Background		 B6.129-Ticam1tm1Tsse
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ticam1tm1Tsse mutation (0 available); any Ticam1 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:118750 )
• natural killer cells from polyI:C-treated mice do not display cytotoxicity towards B16 melanoma cells

neoplasm
increased tumor growth/size ( J:118750 )
• in mice treated with polyI:C the reduction in tumor growth of injected B16 melanoma cells is less than in polyI:C treated control mice

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:118750 )
• natural killer cells from polyI:C-treated mice do not display cytotoxicity towards B16 melanoma cells




Genotype
MGI:5558901
cx2
Allelic
Composition		 Ticam1tm1Tsse/Ticam1tm1Tsse
Tg(PVR)1Kkst/0
Genetic
Background		 involves: 129 * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(PVR)1Kkst mutation (0 available)
Ticam1tm1Tsse mutation (0 available); any Ticam1 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:179625 )
• in polivirus-infected mice at low doses
• however, high doses provides the same lethality as in Tg(PVR)1Kkst mice

immune system
abnormal interferon-alpha secretion ( J:179625 )
• following injection of high poliovirus titers, mice fail to exhibit an increase in serum IFN-alpha Tg(PVR)1Kkst mice
increased susceptibility to Picornaviridae infection ( J:179625 )
• mice infected with low doses of poliovirus exhibit increased organ titers, reduced lethality and fail to exhibit an increase in IFN-alpha serum levels compared with Tg(PVR)1Kkst mice
• mouse embryonic fibroblasts are more susceptible to poliovirus-induced cell death compared with cells from Tg(PVR)1Kkst mice
increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:179625 )
• in polivirus-infected mice at low doses
• however, high doses provides the same lethality as in Tg(PVR)1Kkst mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory