Phenotypes associated with this allele

• Allele Symbol: Grin2b^tm1Tya
• Allele Name: targeted mutation 1, Tadashi Yamamoto
• Allele ID: MGI:3701351
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2b^tm1Tya/Grin2b^tm1Tya	involves: C57BL/6J	MGI:3701799

Genotype
MGI:3701799

hm1

• Allelic Composition: Grin2b^tm1Tya/Grin2b^tm1Tya
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal cued conditioning behavior ( J:119025 )

• mutants show impaired fear-related learning in an auditory fear conditioning test

• mutants show much weaker freezing responses prior to administration of conditioned stimulus in the novel chamber 24 hours after conditioning compared to wild-type

• mice fail to acquire the conditione-unconditioned stimulus association compared to wild-type

nervous system

nervous system phenotype ( J:119025 )

N • mutants show relatively normal basic synaptic transmission properties

abnormal nervous system physiology ( J:119025 )

• thalamo-amygdala afferent tetanic stimulation induces increased Tyr-1472 phosphorylation in mutant brains compared to wild-type

impaired synaptic plasticity ( J:119025 )

• in lateral nucleus of amygdala (LA), long term potentiation is significantly smaller than wild-type when the conditioning stimulus is delivered