Phenotypes associated with this allele

• Allele Symbol: Ptgs2^{tm2(Ptgs1)Fun}
• Allele Name: targeted mutation 2, Colin D Funk
• Allele ID: MGI:3701117
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptgs2^tm2(Ptgs1)Fun/Ptgs2^tm2(Ptgs1)Fun	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3701210

Genotype
MGI:3701210

hm1

• Allelic Composition: Ptgs2^{tm2(Ptgs1)Fun}/Ptgs2^{tm2(Ptgs1)Fun}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:118171 )

• only 16.5% of pups are identified as homozygous at 10-12 days, in contrast to 25% expected

immune system

abnormal macrophage physiology ( J:118171 )

• upon LPS stimulation, induced mutant macrophages do not produce detectable prostaglandin E2 (PGE2)

hematopoietic system

abnormal macrophage physiology ( J:118171 )

• upon LPS stimulation, induced mutant macrophages do not produce detectable prostaglandin E2 (PGE2)