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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptgs2tm2(Ptgs1)Fun
targeted mutation 2, Colin D Funk
MGI:3701117
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptgs2tm2(Ptgs1)Fun/Ptgs2tm2(Ptgs1)Fun involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3701210


Genotype
MGI:3701210
hm1
Allelic
Composition		 Ptgs2tm2(Ptgs1)Fun/Ptgs2tm2(Ptgs1)Fun
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs2tm2(Ptgs1)Fun mutation (0 available); any Ptgs2 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:118171 )
• only 16.5% of pups are identified as homozygous at 10-12 days, in contrast to 25% expected

immune system
abnormal macrophage physiology ( J:118171 )
• upon LPS stimulation, induced mutant macrophages do not produce detectable prostaglandin E2 (PGE2)

hematopoietic system
abnormal macrophage physiology ( J:118171 )
• upon LPS stimulation, induced mutant macrophages do not produce detectable prostaglandin E2 (PGE2)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory