Phenotypes associated with this allele

• Allele Symbol: Ighm^tm2.1Bgmn
• Allele Name: targeted mutation 2.1, Marianne Bruggemann
• Allele ID: MGI:3701077
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ighm^tm2.1Bgmn/Ighm^tm2.1Bgmn	involves: 129/Sv * C57BL/6 * CBA	MGI:3702916

Genotype
MGI:3702916

hm1

• Allelic Composition: Ighm^tm2.1Bgmn/Ighm^tm2.1Bgmn
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

arrested B cell differentiation ( J:118453 )

• B cell development is halted at pre-B cell stage, indicated by lack of CD25+ B-cells

absent mature B cells ( J:118453 )

• in bone marrow and spleen, mature (B220+) B lymphocytes are lacking

decreased immunoglobulin level ( J:118453 )

• no Ig's are detected in the serum of mutants compared to wild-type or Igh-6^tm1Cgn mice

immune system

arrested B cell differentiation ( J:118453 )

• B cell development is halted at pre-B cell stage, indicated by lack of CD25+ B-cells

absent mature B cells ( J:118453 )

• in bone marrow and spleen, mature (B220+) B lymphocytes are lacking

abnormal immune system physiology ( J:118453 )

• transcription of rearranged heavy chains is absent in mutants, despite apparently normal DNA rearrangement

decreased immunoglobulin level ( J:118453 )

• no Ig's are detected in the serum of mutants compared to wild-type or Igh-6^tm1Cgn mice