Analysis Tools
mortality/aging
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• at E10.5, 10% of embryos are found dead while at E14.5, all mutant heterozygotes are dead; data indicates embryos die ~E13.5 from CNS hemorrhage
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embryo
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• liver at E12.5 shows near complete absence of erythroid, myeloid, or megakaryocytic progenitors
• cultured E12.5 fetal liver cells give rise only to macrophage colonies whereas wild-type cells produce multilineage colonies; E13.5 cells give rise to numerous mixed-like colonies
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hematopoietic system
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• liver at E12.5 shows near complete absence of erythroid, myeloid, or megakaryocytic progenitors
• cultured E12.5 fetal liver cells give rise only to macrophage colonies whereas wild-type cells produce multilineage colonies; E13.5 cells give rise to numerous mixed-like colonies
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• postenucleated erythrocytes are absent from peripheral blood of mutant embryos, but are present in wild-type littermates
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immune system
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• postenucleated erythrocytes are absent from peripheral blood of mutant embryos, but are present in wild-type littermates
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cardiovascular system
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• hemorrhage occurs as early as E12.5 in the cerebral ventricle, as well as the dorsal root ganglia
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nervous system
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• hemorrhage occurs as early as E12.5 in the cerebral ventricle, as well as the dorsal root ganglia
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