Phenotypes associated with this allele

• Allele Symbol: Acaca^tm1Jkus
• Allele Name: targeted mutation 1, Jun Kusunokie
• Allele ID: MGI:3700954
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Acaca^tm1Jkus/Acaca^tm1Jkus Tg(Fabp1-cre)1Mmt/0	involves: 129X1/SvJ * C57BL/6J * SJL	MGI:3702023

Genotype
MGI:3702023

cn1

• Allelic Composition: Acaca^tm1Jkus/Acaca^tm1Jkus; Tg(Fabp1-cre)1Mmt/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating aspartate transaminase level ( J:118861 )

• levels are slightly but significantly increased in males compared to wild-type at 9 weeks of age; these levels are still within normal range

abnormal lipid homeostasis ( J:118861 )

• 10-week old males fed a high sucrose (67%) diet (HSD) for 3 days have slightly decreased de novo lipogenesis compared to controls on the HSD, but levels are 3-fold higher than controls fed a normal diet

decreased liver triglyceride level ( J:118861 )

• 10-week old males fed a high sucrose (67%) diet (HSD) for 3 days show ~70% decreased liver triglyceride levels than nontransgenic controls fed HSD

liver/biliary system

decreased liver triglyceride level ( J:118861 )

• 10-week old males fed a high sucrose (67%) diet (HSD) for 3 days show ~70% decreased liver triglyceride levels than nontransgenic controls fed HSD