Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
YwhaqGt(RRR746)Byg mutation
(0 available);
any
Ywhaq mutation
(31 available)
|
|
|
mortality/aging
|
• most embryos die by 14 days post-coitum; most die between 12 and 13 days post-coitum (dpc)
|
embryo
|
• 8- to 11-dpc embryos show signs of growth arrest
|
|
• most embryos examined at 8 and 11 dpc reveal generalized developmental delay
|
|
• at early stages, particularly 8 dpc, deciduae are smaller than wild-type
|
growth/size/body
|
• most embryos examined at 8 and 11 dpc reveal generalized developmental delay
|
|
• at early stages, particularly 8 dpc, deciduae are smaller than wild-type
|
cardiovascular system
N |
• embryos examined at 8 and 11 dpc do not show specific cardiac defects
|
Allelic Composition |
YwhaqGt(RRR746)Byg/Ywhaq+
|
|
Genetic Background |
involves: 129P2/OlaHsd * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
YwhaqGt(RRR746)Byg mutation
(0 available);
any
Ywhaq mutation
(31 available)
|
|
|
mortality/aging
|
• after myocardial infarction surgery, mutant mice show an increased mortality rate over 7 days following surgery; only 7/17 mutants survive 7 days compared to 11/15 wild-type
|
embryo
|
• most embryos examined at 8 and 11 dpc reveal generalized developmental delay
|
growth/size/body
|
• most embryos examined at 8 and 11 dpc reveal generalized developmental delay
|
cardiovascular system
N |
• at 12 weeks, mice do not show notable cardiac morphological or functional differences from wild-type
|
|
• after myocardial infarction surgery, mice that die uniformly show ventricular free wall rupture
|
|
• 1 week after myocardial infarction surgery, mutant mice show marked left ventricular dilatation compared to wild-type
|
|
• end diastolic volume and end systolic volume are increased in mutants at 1 week post myocardial infarction surgery
|
|
• cultured cardiomyocytes show an ~8-fold increased rate of apoptosis in response to UV-C irradiation
• apoptosis across the infarct border zones is greater in mutant tissue than in wild-type
|
|
• 7 days after left coronary artery ligation, infarction size is significantly greater in mutants (48% of left ventricular area vs 32% in wild-type)
|
muscle
|
• cultured cardiomyocytes show an ~8-fold increased rate of apoptosis in response to UV-C irradiation
• apoptosis across the infarct border zones is greater in mutant tissue than in wild-type
|
homeostasis/metabolism
cellular
|
• cultured cardiomyocytes show an ~8-fold increased rate of apoptosis in response to UV-C irradiation
• apoptosis across the infarct border zones is greater in mutant tissue than in wild-type
|