Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syne2tm1Rexu mutation
(0 available);
any
Syne2 mutation
(297 available)
|
|
|
muscle
N |
• mice do not show abnormal myonuclear positioning
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syne1tm1Rexu mutation
(0 available);
any
Syne1 mutation
(202 available)
Syne2tm1Rexu mutation
(0 available);
any
Syne2 mutation
(297 available)
|
|
|
mortality/aging
|
• double homozygotes are born, but die within 20 minutes
|
respiratory system
|
• mice fail to move their ribcages, but can move limbs in response to stimuli
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• mice are unable to breathe
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nervous system
|
• phrenic nerve-diaphragm neuromuscular synapses have broader endplates than controls
|
|
• phrenic nerve has significantly longer branches than controls
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syne1tm1Rexu mutation
(0 available);
any
Syne1 mutation
(202 available)
Syne2tm1Rexu mutation
(0 available);
any
Syne2 mutation
(297 available)
|
|
|
nervous system
|
• phrenic nerve-diaphragm neuromuscular synapses have broader endplates than controls
|
|
• phrenic nerve has significantly longer branches than controls
|