Phenotypes associated with this allele

• Allele Symbol: Nedd9^tm1Miku
• Allele Name: targeted mutation 1, Mineo Kurokawa
• Allele ID: MGI:3700233
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nedd9^tm1Miku/Nedd9^tm1Miku	B6.CBA-Nedd9^tm1Miku	MGI:3700956

Genotype
MGI:3700956

hm1

• Allelic Composition: Nedd9^tm1Miku/Nedd9^tm1Miku
• Genetic Background: B6.CBA-Nedd9^tm1Miku

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal leukocyte migration ( J:116716 )

• mutant splenocytes injected into wild-type hosts show abnormal homing with numbers of homing mutant cells found in spleen and lymph nodes decreased compared to wild-type cells

abnormal B cell number ( J:116716 )

increased follicular B cell number ( J:116716 )

• follicular zone B cells (FOB, B-2 cells) are concomitantly increased

decreased lymphocyte cell number ( J:116716 )

• there are reduced lymphocyte numbers in peripheral lymphoid organs in mutants

decreased marginal zone B cell number ( J:116716 )

• marginal zone B cell numbers are reduced in mutants, as shown by reduced CD1d^high cell numbers or IgM^highIgD^low cell numbers

spleen hypoplasia ( J:116716 )

• splenocyte number is ~50% of wild-type; both B and T cell numbers are reduced, with B cells more affected

abnormal follicular B cell physiology ( J:116716 )

• follicular zone B cells show aberrant migration and adhesion in response to chemotactic stimuli, compared to wild-type cells

abnormal T cell physiology ( J:116716 )

• splenic T cells show attenuated responses to chemotactic (CXCL12 and CCL21) stimuli

immune system

abnormal leukocyte migration ( J:116716 )

• mutant splenocytes injected into wild-type hosts show abnormal homing with numbers of homing mutant cells found in spleen and lymph nodes decreased compared to wild-type cells

abnormal B cell number ( J:116716 )

increased follicular B cell number ( J:116716 )

• follicular zone B cells (FOB, B-2 cells) are concomitantly increased

decreased lymphocyte cell number ( J:116716 )

• there are reduced lymphocyte numbers in peripheral lymphoid organs in mutants

decreased marginal zone B cell number ( J:116716 )

• marginal zone B cell numbers are reduced in mutants, as shown by reduced CD1d^high cell numbers or IgM^highIgD^low cell numbers

spleen hypoplasia ( J:116716 )

• splenocyte number is ~50% of wild-type; both B and T cell numbers are reduced, with B cells more affected

abnormal follicular B cell physiology ( J:116716 )

• follicular zone B cells show aberrant migration and adhesion in response to chemotactic stimuli, compared to wild-type cells

abnormal T cell physiology ( J:116716 )

• splenic T cells show attenuated responses to chemotactic (CXCL12 and CCL21) stimuli

lymph node hypoplasia ( J:116716 )

• total number of lymphocytes and numbers of T and B cells is significantly reduced compared to wild-type

cellular

abnormal leukocyte migration ( J:116716 )

• mutant splenocytes injected into wild-type hosts show abnormal homing with numbers of homing mutant cells found in spleen and lymph nodes decreased compared to wild-type cells