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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chrna4tm1Jbou
targeted mutation 1, Jim Boulter
MGI:3700204
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chrna4tm1Jbou/Chrna4tm1Jbou either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J) MGI:3700259
ht2
 		Chrna4tm1Jbou/Chrna4+ either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J) MGI:3700258


Genotype
MGI:3700259
hm1
Allelic
Composition		 Chrna4tm1Jbou/Chrna4tm1Jbou
Genetic
Background		 either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna4tm1Jbou mutation (1 available); any Chrna4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavioral arrest ( J:118273 )
• observed during seizures
seizures ( J:118273 )
• mice exhibit spontaneous recurrent seizures, ranging from 1-5s of behavioral arrest to extended (2-60 seconds) of rhythmic jerking movements of extremities, with loss of balance and falling over

nervous system
abnormal nervous system physiology ( J:118273 )
• mutants show abnormal EEG activity during seizure episodes, such as repetitive discharges with paroxysmal onset and sudden termination with asymmetric rhythm patterns; this is observed for 21.5% of a 4-hour recording period
seizures ( J:118273 )
• mice exhibit spontaneous recurrent seizures, ranging from 1-5s of behavioral arrest to extended (2-60 seconds) of rhythmic jerking movements of extremities, with loss of balance and falling over
abnormal brain wave pattern ( J:118273 )
• mutants show abnormal EEG activity during seizure episodes, such as repetitive discharges with paroxysmal onset and sudden termination with asymmetric rhythm patterns; this is observed for 21.5% of a 4-hour recording period




Genotype
MGI:3700258
ht2
Allelic
Composition		 Chrna4tm1Jbou/Chrna4+
Genetic
Background		 either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna4tm1Jbou mutation (1 available); any Chrna4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavioral arrest ( J:118273 )
• observed during seizures
seizures ( J:118273 )
• mice exhibit spontaneous recurrent seizures, ranging from 1-5s of behavioral arrest to extended (2-60 seconds) of rhythmic jerking movements of extremities, with loss of balance and falling over

nervous system
seizures ( J:118273 )
• mice exhibit spontaneous recurrent seizures, ranging from 1-5s of behavioral arrest to extended (2-60 seconds) of rhythmic jerking movements of extremities, with loss of balance and falling over
abnormal brain wave pattern ( J:118273 )
• mutants show abnormal EEG activity during seizure episodes, such as repetitive discharges with paroxysmal onset and sudden termination with asymmetric rhythm patterns; this is observed for 22% of a 4-hour recording period
abnormal inhibitory postsynaptic currents ( J:118273 )
• frequency and amplitude of spontaneous IPSCs are increased in pyramidal cells with application of nicotine; mean inhibitory current is increased 23.4-fold with nicotine treatment vs 2.5-fold in wild-type cells




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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory