About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(KRT14-RAF1/ESR1)1Pkha
transgene insertion 1, Paul A Khavari
MGI:3700057
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
Tg(KRT14-RAF1/ESR1)1Pkha/? 		involves: 129/Sv * C57BL/6 * C57BL/6J * SJL MGI:3714930
tg2
 		Tg(KRT14-RAF1/ESR1)1Pkha/0 involves: C57BL/6 MGI:3700918


Genotype
MGI:3714930
cx1
Allelic
Composition		 Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
Tg(KRT14-RAF1/ESR1)1Pkha/?
Genetic
Background		 involves: 129/Sv * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1tm1Chrn mutation (1 available); any Map2k1 mutation (92 available)
Map2k2tm1Chrn mutation (1 available); any Map2k2 mutation (35 available)
Tg(KRT14-RAF1/ESR1)1Pkha mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
skin hypoplasia ( J:122484 )
• following tamoxifen treatment, mice have increased epidermal hypoplasia and increased cell death




Genotype
MGI:3700918
tg2
Allelic
Composition		 Tg(KRT14-RAF1/ESR1)1Pkha/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-RAF1/ESR1)1Pkha mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
hyperkeratosis ( J:81660 )
• with continuous 4-hydroxy-testosterone (4OHT) application, hyperkeratosis is observed after 3 weeks
thick skin ( J:81660 )
• with continuous 4-hydroxy-testosterone (4OHT) application, skin thickening is observed after 3 weeks




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory