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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(KRT14-RAF1/ESR1)1Pkha
transgene insertion 1, Paul A Khavari
MGI:3700057
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
Tg(KRT14-RAF1/ESR1)1Pkha/? 		involves: 129/Sv * C57BL/6 * C57BL/6J * SJL MGI:3714930
tg2
 		Tg(KRT14-RAF1/ESR1)1Pkha/0 involves: C57BL/6 MGI:3700918


Genotype
MGI:3714930
cx1
Allelic
Composition		 Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
Tg(KRT14-RAF1/ESR1)1Pkha/?
Genetic
Background		 involves: 129/Sv * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1tm1Chrn mutation (1 available); any Map2k1 mutation (94 available)
Map2k2tm1Chrn mutation (1 available); any Map2k2 mutation (34 available)
Tg(KRT14-RAF1/ESR1)1Pkha mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
skin hypoplasia ( J:122484 )
• following tamoxifen treatment, mice have increased epidermal hypoplasia and increased cell death




Genotype
MGI:3700918
tg2
Allelic
Composition		 Tg(KRT14-RAF1/ESR1)1Pkha/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-RAF1/ESR1)1Pkha mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
hyperkeratosis ( J:81660 )
• with continuous 4-hydroxy-testosterone (4OHT) application, hyperkeratosis is observed after 3 weeks
thick skin ( J:81660 )
• with continuous 4-hydroxy-testosterone (4OHT) application, skin thickening is observed after 3 weeks




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory