Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sulf1tm1Clrm mutation
(1 available);
any
Sulf1 mutation
(110 available)
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mortality/aging
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• mortality in the first month of life is slightly but consistently increased
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cellular
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• in primary MEFs in response to mitogenic stimulation
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skeleton
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• all mice exhibit incomplete closure of the basisphenoid bone
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• at P0, the length of the radius is decreased 91% of wild-type
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• at P0/P1, all exhibit sternebrae fusion with 29% exhibiting fusion between the manubrium and 2 or 4 sternebrae
• all mice exhibit fusion of sternebra 3 and 4 and 40% of mice exhibit partial fusion of sternebra 2 and 3
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• at P0, sternum length is decreased 84% of wild-type
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• after P21, 80% of mice exhibit calcified fusion of up to 7 distal tail vertebrae
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• at P0/P1, 50% of mice exhibit fusions in up to 12 vertebrae including some in the thoracic region
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• 11 of 20 mice exhibit dorsally malformed second cervical vertebra
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• at P0/P1, 50% of mice exhibit fusions in up to 12 vertebrae including some in the thoracic region
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• at P0/P1, 50% of mice exhibit fusions in up to 12 vertebrae including some in the thoracic region
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• at P21, 100% of mice exhibit split dorsal vertebrae compared to 22% of wild-type mice with 80% of mice exhibiting involvement of 2 to 6 vertebrae
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limbs/digits/tail
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• at P0, the length of the radius is decreased 91% of wild-type
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• after P21, 80% of mice exhibit calcified fusion of up to 7 distal tail vertebrae
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craniofacial
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• all mice exhibit incomplete closure of the basisphenoid bone
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mortality/aging
reproductive system
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• the few fertile adults obtained produce litters that are about 2-fold smaller than controls
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growth/size/body
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• obvious reduction in body mass
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cellular
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• unable to keep primary MEFs alive in culture for very long
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