Phenotypes associated with this allele

• Allele Symbol: Tg(Myhca-Casq2)418Egk
• Allele Name: transgene insertion 418, Evangelia G Kranias
• Allele ID: MGI:3699603
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myhca-Casq2)418Egk/0	involves: FVB/N	MGI:3715375

Genotype
MGI:3715375

tg1

• Allelic Composition: Tg(Myhca-Casq2)418Egk/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:50498 )

• mild myocyte hypertrophy in the left ventricular free walls and intraventricular septa

cardiac hypertrophy ( J:50498 )

• increase in heart/body weight ratio is associated with increases in expression of fetal genes

abnormal cardiovascular system physiology ( J:50498 )

decreased cardiac muscle contractility ( J:50498 )

• cardiomyocyte (isolated) shortening and maximal rates of shortening are depressed by 46 and 60%, respectively

• left ventricular function analysis in Langerdorff perfused hearts and closed-chest anesthetized mice show a depressed rate of contraction of hearts

abnormal cardiac muscle relaxation ( J:50498 )

• cardiomyocyte relengthening rate is depressed by 60%

• left ventricular function analysis in Langerdorff perfused hearts and closed-chest anesthetized mice show a depressed rate of relaxation of hearts

abnormal myocardial fiber physiology ( J:50498 )

• the calcium transient amplitude of cardiomyocytes is depressed (45%), although the SR calcium storage capacity is augmented

• cardiomyocytes exhibit a decrease in L-type calcium current density and prolongation of the channels inactivation kinetics without changes in sodium-calcium exchanger current density

muscle

increased myocardial fiber size ( J:50498 )

• mild myocyte hypertrophy in the left ventricular free walls and intraventricular septa

decreased cardiac muscle contractility ( J:50498 )

• cardiomyocyte (isolated) shortening and maximal rates of shortening are depressed by 46 and 60%, respectively

• left ventricular function analysis in Langerdorff perfused hearts and closed-chest anesthetized mice show a depressed rate of contraction of hearts

abnormal cardiac muscle relaxation ( J:50498 )

• cardiomyocyte relengthening rate is depressed by 60%

• left ventricular function analysis in Langerdorff perfused hearts and closed-chest anesthetized mice show a depressed rate of relaxation of hearts

growth/size/body

cardiac hypertrophy ( J:50498 )

• increase in heart/body weight ratio is associated with increases in expression of fetal genes