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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pif1tm1Leah
targeted mutation 1, Lea Harrington
MGI:3699312
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pif1tm1Leah/Pif1tm1Leah B6.129P2-Pif1tm1Leah MGI:3699813
hm2
 		Pif1tm1Leah/Pif1tm1Leah involves: 129P2/OlaHsd * C57BL/6 MGI:3699812


Genotype
MGI:3699813
hm1
Allelic
Composition		 Pif1tm1Leah/Pif1tm1Leah
Genetic
Background		 B6.129P2-Pif1tm1Leah
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pif1tm1Leah mutation (0 available); any Pif1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:118302 )
• mice are normal with no apparent changes in telomere length in ES cells, thymocytes or splenocytes




Genotype
MGI:3699812
hm2
Allelic
Composition		 Pif1tm1Leah/Pif1tm1Leah
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pif1tm1Leah mutation (0 available); any Pif1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased telomere length ( J:118302 )
• a significant increase in telomere length was observed in ES cells from one litter from homozygous matings after 4 generations; this was not observed in other litters and was no longer apparent after 5 and 6 generations




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory