Phenotypes associated with this allele

• Allele Symbol: Lmtk2^tm1Tya
• Allele Name: targeted mutation 1, Tadashi Yamamoto
• Allele ID: MGI:3699255
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lmtk2^tm1Tya/Lmtk2^tm1Tya	involves: 129P2/OlaHsd * C57BL/6	MGI:3700038

Genotype
MGI:3700038

hm1

• Allelic Composition: Lmtk2^tm1Tya/Lmtk2^tm1Tya
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Azoospermia in Lmtk2^tm1Tya/Lmtk2^tm1Tya mice

cellular

azoospermia ( J:118247 )

♂

mortality/aging

prenatal lethality, incomplete penetrance ( J:118247 )

• about 7% die before birth

reproductive system

reproductive system phenotype ( J:118247 )

N • despite azoospermia, morphology of Sertoli and Leydig cells is similar to wild-type controls

azoospermia ( J:118247 )

♂

small testis ( J:118247 )

♂ • smaller than wild-type at 8 weeks of age but not in mice at 3 or 4 weeks of age

arrest of spermatogenesis ( J:118247 )

♂ • differentiation beyond S1 (round spermatid stage) is severely impaired

male infertility ( J:118247 )

♂ • only males are infertile

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:118247 )

N • circulating levels of testosterone, luteinizing hormone, and follicle-stimulating hormone are all similar to wild-type controls indicating hormone abnormalities do no contribute to azoospermia and male infertility

nervous system

nervous system phenotype ( J:118247 )

N • despite high levels of expression, no histological abnormalities are found in the nervous system

endocrine/exocrine glands

small testis ( J:118247 )

♂ • smaller than wild-type at 8 weeks of age but not in mice at 3 or 4 weeks of age