Phenotypes associated with this allele

• Allele Symbol: Dmrta1^tm1.1Zark
• Allele Name: targeted mutation 1.1, David Zarkower
• Allele ID: MGI:3699123
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dmrta1^tm1.1Zark/Dmrta1^tm1.1Zark	involves: 129S1/Sv * FVB/N	MGI:3701228
ht2	Dmrta1^tm1.1Zark/Dmrta1^+	involves: 129S1/Sv * FVB/N	MGI:3701229

Genotype
MGI:3701228

hm1

• Allelic Composition: Dmrta1^tm1.1Zark/Dmrta1^tm1.1Zark
• Genetic Background: involves: 129S1/Sv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

polyovular ovarian follicle ( J:118110 )

♀ • most mutant ovaries contain at least one polyovular follicle

♀ • most are biovular, but as many as five oocytes have been observed

behavior/neurological

behavior/neurological phenotype ( J:118110 )

N • mice don't display any apparent motor deficits

N • females do not show increased aggressiveness toward male intruders compared to wild-type

abnormal sexual interaction ( J:118110 )

♂ • male mutants display significantly greater same-sex mounting behavior compared to wild-type (4/16 vs 0 wild-type); proportion of animals with this behavior is low, but consistent upon repeated testing

♂ • occurrence of mounts that are clearly sexual is greater than in wild-type or heterozygotes

abnormal mating preference ( J:118110 )

♂ • 25% of mutant males consistently display copulatory behavior toward other males

endocrine/exocrine glands

polyovular ovarian follicle ( J:118110 )

♀ • most mutant ovaries contain at least one polyovular follicle

♀ • most are biovular, but as many as five oocytes have been observed

skeleton

skeleton phenotype ( J:118110 )

N • there are no apparent defects in bone or cartilage development

taste/olfaction

taste/olfaction phenotype ( J:118110 )

N • males show relatively normal olfactory detection of food or pheromones

Genotype
MGI:3701229

ht2

• Allelic Composition: Dmrta1^tm1.1Zark/Dmrta1⁺
• Genetic Background: involves: 129S1/Sv * FVB/N

behavior/neurological

abnormal sexual interaction ( J:118110 )

♂ • male mutants display significantly greater same-sex mounting behavior compared to wild-type (2/27 vs 0 wild-type); proportion of animals with this behavior is low, but consistent upon repeated testing

♂ • occurrence of mounts that are clearly sexual is greater than in wild-type

endocrine/exocrine glands

polyovular ovarian follicle ( J:118110 )

♀ • some mutant ovaries (2/6) contain polyovular follicles

reproductive system

polyovular ovarian follicle ( J:118110 )

♀ • some mutant ovaries (2/6) contain polyovular follicles