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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapkapk3tm1.1Lex
targeted mutation 1.1, Lexicon Genetics
MGI:3698628
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mapkapk3tm1.1Lex/Mapkapk3tm1.1Lex involves: 129S/SvEvBrd * C57BL/6 MGI:3698630
cx2
 		Mapkapk2tm1Mgl/Mapkapk2tm1Mgl
Mapkapk3tm1.1Lex/Mapkapk3tm1.1Lex 		involves: 129P2/OlaHsd * 129S/SvEvBrd * C57BL/6 MGI:3698632


Genotype
MGI:3698630
hm1
Allelic
Composition		 Mapkapk3tm1.1Lex/Mapkapk3tm1.1Lex
Genetic
Background		 involves: 129S/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk3tm1.1Lex mutation (0 available); any Mapkapk3 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:117668 )
N
• LPS-induce cytokine production is similar to wild-type mice




Genotype
MGI:3698632
cx2
Allelic
Composition		 Mapkapk2tm1Mgl/Mapkapk2tm1Mgl
Mapkapk3tm1.1Lex/Mapkapk3tm1.1Lex
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk2tm1Mgl mutation (0 available); any Mapkapk2 mutation (36 available)
Mapkapk3tm1.1Lex mutation (0 available); any Mapkapk3 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:117668 )
N
• in contrast to expectations, mice are viable

immune system
abnormal cytokine secretion ( J:117668 )
• LPS-induced production of tristetraprolin and TNF is reduced compared to wild-type mice and compared to Mapkapk2 single homozygotes

embryo
embryo phenotype ( J:117668 )
N
• in contrast to expectations, no defects in embryonic development are detected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory