Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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hematopoietic system
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• a subpopulation of CD4 SP thymocytes derived in vivo, from transferred E13.5 day livers show surface expression similar to double positive (DP) thymocytes (except lacking CD8 expression)
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immune system
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N |
• no defect is detected in competitive repopulation assays, suggesting the decrease in T cell numbers is a result of decreased body size
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• a subpopulation of CD4 SP thymocytes derived in vivo, from transferred E13.5 day livers show surface expression similar to double positive (DP) thymocytes (except lacking CD8 expression)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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hematopoietic system
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• there is dramatic change in CD4 vs CD8 expression profile compared to wild-type
• a subpopulation of CD4 SP thymocytes show surface expression similar to double positive (DP) thymocytes (except lacking CD8 expression)
• intraepithelial lymphocytes (IEL) lose CD8a expression on TCR gamma/delta lineage cells whereas Cc8atm1.1Litt cells have normal CD8a levels
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• percentage is decreased compared to controls (from 84% to 65%)
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• in thymic lobes after 3 days in culture, ratio of CD4 single positive cells to double positive cells is much higher than in cultured heterozygous organs; percentage of immature CD8 SP thymocytes is seen
• "CD8-negative" SP cells emerge to a significant extent after 7 days of culture, coincident with development of double positive cells
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• increased CD4 single positive (SP) cell number from 11% in controls to 29%
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• percentage (1.8%) and absolute numbers of CD8+ SP cells (1.9 x106) in thymus of mutants are decreased compared to controls (4.5%, 2.8 x x106 respectively)
• CD8+ T cell numbers in periphery (lymph nodes and spleen) are decreased vs controls
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immune system
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• there is dramatic change in CD4 vs CD8 expression profile compared to wild-type
• a subpopulation of CD4 SP thymocytes show surface expression similar to double positive (DP) thymocytes (except lacking CD8 expression)
• intraepithelial lymphocytes (IEL) lose CD8a expression on TCR gamma/delta lineage cells whereas Cc8atm1.1Litt cells have normal CD8a levels
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• percentage is decreased compared to controls (from 84% to 65%)
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• in thymic lobes after 3 days in culture, ratio of CD4 single positive cells to double positive cells is much higher than in cultured heterozygous organs; percentage of immature CD8 SP thymocytes is seen
• "CD8-negative" SP cells emerge to a significant extent after 7 days of culture, coincident with development of double positive cells
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• increased CD4 single positive (SP) cell number from 11% in controls to 29%
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• percentage (1.8%) and absolute numbers of CD8+ SP cells (1.9 x106) in thymus of mutants are decreased compared to controls (4.5%, 2.8 x x106 respectively)
• CD8+ T cell numbers in periphery (lymph nodes and spleen) are decreased vs controls
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Allelic
Composition |
Rr100tm2.1Welm/Rr100+
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Genetic
Background |
involves: 129P2/OlaHsd * AKR.1 * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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hematopoietic system
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• mice with one mutant Cd8a allele and a wild-type AKR.1 derived allele have ""CD8-negative"" single positive (SP) thymocytes expressing no CD8 alpha or beta
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immune system
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• mice with one mutant Cd8a allele and a wild-type AKR.1 derived allele have ""CD8-negative"" single positive (SP) thymocytes expressing no CD8 alpha or beta
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr100tm2.1Welm mutation
(0 available);
any
Rr100 mutation
(0 available)
Tcratm1Mom mutation
(6 available);
any
Tcra mutation
(98 available)
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hematopoietic system
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• mice have population of abnormal "CD8-negative" SP thymocytes
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immune system
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• mice have population of abnormal "CD8-negative" SP thymocytes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Patz1tm1.1Welm mutation
(0 available);
any
Patz1 mutation
(55 available)
Rr100tm2.1Welm mutation
(0 available);
any
Rr100 mutation
(0 available)
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immune system
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N |
• unlike mice with a wild-type copy of Patz, null mice have no defects in T cell differentiation
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Analysis Tools