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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Thoc1tm2Dwg
targeted mutation 2, David W Goodrich
MGI:3698313
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Thoc1tm2Dwg/Thoc1tm2Dwg involves: 129S4/SvJae * C57BL/6J MGI:3698528
ht2
 		Thoc1tm1Dwg/Thoc1tm2Dwg involves: 129S4/SvJae * C57BL/6J MGI:3698530


Genotype
MGI:3698528
hm1
Allelic
Composition		 Thoc1tm2Dwg/Thoc1tm2Dwg
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thoc1tm2Dwg mutation (0 available); any Thoc1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
decreased embryo size ( J:117869 )
• small size is detectable as early as E12.5

growth/size/body
decreased embryo size ( J:117869 )
• small size is detectable as early as E12.5
decreased body size ( J:117869 )
• 100% penetrance; reduced size persists throughout adulthood
decreased body weight ( J:117869 )
• in adulthood, weight is about 80% of wild-type




Genotype
MGI:3698530
ht2
Allelic
Composition		 Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thoc1tm1Dwg mutation (0 available); any Thoc1 mutation (43 available)
Thoc1tm2Dwg mutation (0 available); any Thoc1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:117869 )
• embryos are detected at E13.5 but no viable neonates are recovered indicating lethality after E13.5 but before birth

embryo

growth/size/body
decreased embryo size ( J:117869 )




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory