Analysis Tools
mortality/aging
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• no female homozygotes are born
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Allele Symbol Allele Name Allele ID |
Tsixtm3Jtl targeted mutation 3, Jeannie T Lee MGI:3698272 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no female homozygotes are born
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only 10-20% of mutants survive to adulthood, when the allele is transmitted maternally
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• paternal transmission has no effect on viability
• mutants die during the implantation stage when allele is transmitted maternally; ~20% of mutant blastocysts bearing maternal allele fail to attach in culture and ~60% show sparse trophoblast outgrowth and degenerate after several days in culture, whereas wild-type blastocysts show robust growth for up to 7 days
• ex vivo, no obvious defects are observed during preimplantation stage
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• female mutants produce smaller litters
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• live births carrying mutant allele are decreased (males: 40 wild-type, 11 mutant and females: 66 wild-type, 6 mutant whereas ratio of mutants to wild-type for both sexes expected is 50:50); 75-90% of mutants bearing maternal allele die
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only 10-20% of mutants survive to adulthood, when the allele is transmitted maternally
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• with maternal transmission of mutant allele, viability is dramatically decreased
• ~20% of mutant blastocysts bearing maternal allele fail to attach in culture and ~60% show sparse trophoblast outgrowth and degenerate after several days in culture, whereas wild-type blastocysts show robust growth for up to 7 days
• paternal transmission has no effect on viability
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• live births carrying mutant allele are decreased (males: 40 wild-type, 11 mutant and females: 66 wild-type, 6 mutant whereas ratio of mutants to wild-type for both sexes expected is 50:50); 75-90% of mutants bearing maternal allele die
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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