Phenotypes associated with this allele

• Allele Symbol: Adipor1^tm1Tka
• Allele Name: targeted mutation 1, Takashi Kadowaki
• Allele ID: MGI:3698268
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adipor1^tm1Tka/Adipor1^tm1Tka	involves: 129S4/SvJae * C57BL/6	MGI:3698982
cx2	Adipor1^tm1Tka/Adipor1^tm1Tka Adipor2^tm1Tka/Adipor2^tm1Tka	involves: 129S4/SvJae * C57BL/6	MGI:3698983

Genotype
MGI:3698982

hm1

• Allelic Composition: Adipor1^tm1Tka/Adipor1^tm1Tka
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:117919 )

• endogenous glucose production (EGP) is increased and glucose infusion rate (GIR) is decreased during hyperglycemic euglycemic clamp, compared to control wild-type, indicating hepatic glucose production and insulin resistance

increased circulating glucose level ( J:117919 )

• in fed mice, plasma glucose levels are higher than in wild-type

• in an oral glucose tolerance test, mutants show significantly increased plasma levels

• pyruvate-induced rise in plasma glucose is increased in mutants

hyperglycemia ( J:117919 )

increased circulating insulin level ( J:117919 )

• in fed mice, plasma insulin levels are higher than in wild-type

• in an oral glucose tolerance test, mutants show significantly increased plasma levels

impaired glucose tolerance ( J:117919 )

• mutants show significant impairment in oral glucose tolerance test

• on a high fat diet, mice exhibit significantly impaired glucose tolerance

insulin resistance ( J:117919 )

• mice develop significant glucose resistance

abnormal enzyme/coenzyme activity ( J:117919 )

• adiponectin-mediated AMPK activation is reduced compared to wild-type or Adipor2-null mice

Genotype
MGI:3698983

cx2

• Allelic Composition: Adipor1^tm1Tka/Adipor1^tm1Tka; Adipor2^tm1Tka/Adipor2^tm1Tka
• Genetic Background: involves: 129S4/SvJae * C57BL/6

homeostasis/metabolism

abnormal glucose homeostasis ( J:117919 )

• endognenous glucose production (EGP) is increased while glucose infusion rate (GIR) and glucose disposal are decreased compared to wild-type

abnormal circulating glucose level ( J:117919 )

• treatment with adiponectin does not reduce plasma glucose levels in mutants compared to significant reduction observed in wild-type

• pyruvate-induced rise in plasma glucose is significantly increased in mutants

hyperglycemia ( J:117919 )

abnormal gluconeogenesis ( J:117919 )

• levels of molecules involved in gluconeogenesis are increased, as well as molecules involved in fatty acid synthesis

impaired glucose tolerance ( J:117919 )

• mice show marked glucose intolerance

• on a high fat diet, mice exhibit significantly impaired glucose tolerance

insulin resistance ( J:117919 )

• insulin resistance index is elevated compared to Adipor1-null mice

• increased hepatic glucose production and insulin resistance in the liver is observed; potentially decreased glucose uptake and mild insulin resistance are seen in skeletal muscle

increased liver triglyceride level ( J:117919 )

• tissue triglyceride content in liver is increased

abnormal enzyme/coenzyme activity ( J:117919 )

• Irs2 tyrosine phosphorylation and insulin stimulated Akt phosphorylation are decreased compared to wild-type

liver/biliary system

increased liver triglyceride level ( J:117919 )

• tissue triglyceride content in liver is increased