Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sulf2Gt(XST155)Byg mutation
(1 available);
any
Sulf2 mutation
(176 available)
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mortality/aging
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N |
• Background Sensitivity: on congenic B6 background, normal Mendelian numbers of homozygous pups are observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sulf2Gt(XST155)Byg mutation
(1 available);
any
Sulf2 mutation
(176 available)
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mortality/aging
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N |
• Background Sensitivity: on this background, lethality is not observed compared to the mixed B6 background
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reproductive system
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• homozygotes do not exhibit significantly reduced fertility when crossed to wild-type males, but when crossed to homozygous males, litter size is reduced (from ~8 pups/litter to 3 pups/litter)
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• homozygotes do not exhibit significantly reduced fertility when crossed to wild-type females, but when crossed to homozygous females, litter size is reduced (from ~8 pups/litter to 3 pups/litter)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sulf2Gt(XST155)Byg mutation
(1 available);
any
Sulf2 mutation
(176 available)
|
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mortality/aging
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• at 3 weeks, number of homozygous mice is 48% of wild-type and only 29% of expected Mendelian number
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• significantly fewer homozygous embryos are found at E13.5 and 14.5; dead embryos appear to have terminated sometime from E10.5 to 12.5
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growth/size/body
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• many homozygous embryos and their placentas are smaller than wild-type embryos
• Background Sensitivity: at N3F3 generation (intercross of hets after third backcross to B6), expected number of homozygotes is obtained
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• some homozygous pups (6/8 total runted pups) are severely runted with weights ~50% that of littermates at birth; runted mice are euthanized at various time points for health reasons
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• many homozygotes appear smaller than littermates after weaning, and weigh significantly less than wild-type littermates at 41.5 days
• at 1 year, homozygous mice have weights ~25% lower than littermates
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embryo
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• many homozygous embryos and their placentas are smaller than wild-type embryos
• Background Sensitivity: at N3F3 generation (intercross of hets after third backcross to B6), expected number of homozygotes is obtained
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respiratory system
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• 3 runted mice exhibited enlarged airspaces
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• a portion of runted homozygotes gasp after birth, suggesting respiratory distress and lung problems
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sulf2Gt(XST155)Byg mutation
(1 available);
any
Sulf2 mutation
(176 available)
|
|
|
mortality/aging
|
N |
• Background Sensitivity: on this background, lethality is not observed compared to the mixed B6 background
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Allelic
Composition |
Sulf2Gt(XST155)Byg/Sulf2+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sulf2Gt(XST155)Byg mutation
(1 available);
any
Sulf2 mutation
(176 available)
|
|
|
growth/size/body
|
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• some heterozygous pups (2/8 total runted pups) are severely runted with weights ~50% that of littermates at birth
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mortality/aging
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• numbers of homozygotes produced is reduced by ~30% from expected numbers; no age when loss occurs is indicated
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Analysis Tools
