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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Camkk1tm1Tch
targeted mutation 1, Talal A Chatila
MGI:3697455
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Camkk1tm1Tch/Camkk1tm1Tch involves: 129X1/SvJ * C57BL/6 MGI:3697816
cx2
 		Camkk1tm1Tch/Camkk1tm1Tch
Camkk2tm1Tch/Camkk2tm1Tch 		involves: 129X1/SvJ MGI:4941485


Genotype
MGI:3697816
hm1
Allelic
Composition		 Camkk1tm1Tch/Camkk1tm1Tch
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camkk1tm1Tch mutation (1 available); any Camkk1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal contextual conditioning behavior ( J:117630 )
• exhibit significantly less freezing at 24h and 10, 30, and 63 days in a long-term fear memory context test
• however, freezing in long term fear cued (tone) test is similar to wild-type, no difference in anxiety related behavior is found, and no motor defects are detected

nervous system
nervous system phenotype ( J:117630 )
N
• basal synaptic transmission and long term potentiation in CA1 neurons are similar to wild-type

reproductive system




Genotype
MGI:4941485
cx2
Allelic
Composition		 Camkk1tm1Tch/Camkk1tm1Tch
Camkk2tm1Tch/Camkk2tm1Tch
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camkk1tm1Tch mutation (1 available); any Camkk1 mutation (20 available)
Camkk2tm1Tch mutation (1 available); any Camkk2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:169657 )
• axons and dendrites of cortical neurons are shortened compared to in wild-type cells
abnormal dendrite morphology ( J:169657 )
• axons and dendrites of cortical neurons are shortened compared to in wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory