Phenotypes associated with this allele

• Allele Symbol: G6pc3^tm1Rmob
• Allele Name: targeted mutation 1, Richard M O'Brien
• Allele ID: MGI:3697438
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	G6pc3^tm1Rmob/G6pc3^tm1Rmob	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3697620

Genotype
MGI:3697620

hm1

• Allelic Composition: G6pc3^tm1Rmob/G6pc3^tm1Rmob
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:117664 )

• females, but not males, weight less at 4 months of age

decreased body length ( J:117664 )

• females, but not males, are shorter at 4 months of age

postnatal growth retardation ( J:117664 )

• females, but not males, exhibit growth retardation

homeostasis/metabolism

increased circulating glucagon level ( J:117664 )

• females, but not males, show a 60% elevation in plasma glucagon levels after a 6 hour fast

decreased circulating cholesterol level ( J:117664 )

• females, but not males, show a 20% reduction in plasma cholesterol levels after a 6 hour fast

• however, show no differences in hepatic glycogen content, blood glucose, triglyceride, glycerol, nonesterified fatty free acid, or insulin levels

endocrine/exocrine glands

increased pancreatic alpha cell number ( J:117664 )

• after a 6 hour fast, females show an increase in alpha cell numbers