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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CAG-Aes,-ALPP)1Lbe
transgene insertion 1, Corrinne Lobe
MGI:3697400
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(CAG-Aes,-ALPP)1Lbe/0
Tg(CAG-Tle1,-ALPP)1Lbe/0 		involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3697422
tg2
 		Tg(CAG-Aes,-ALPP)1Lbe/0 involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3697421


Genotype
MGI:3697422
cx1
Allelic
Composition		 Tg(CAG-Aes,-ALPP)1Lbe/0
Tg(CAG-Tle1,-ALPP)1Lbe/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor susceptibility ( J:106684 )
• only 50% (6/12) double transgenic mice have visible tumors on the pleural surface compared to 96% (27/28) of Tg(ACTB-Tle1,-ALPP)1Lbe single transgenics at 6 months of age
• average number of visible tumors is 2.4 compared to 8.3 in single transgenic mice; tumors are substantially smaller in addition to being decreased in number




Genotype
MGI:3697421
tg2
Allelic
Composition		 Tg(CAG-Aes,-ALPP)1Lbe/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:106684 )
• mice are viable and fertile, with no obvious phenotypic abnormalities




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory